Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — IGF2

Text-mined interactions from Literome

Ahmad et al., J Immunol 2000 : In F/V cells, IGF-1 increased PKB , PDE3B, and PDE4 activities approximately 2-fold ... In F/B cells, IGF-1 , in a wortmannin-sensitive manner, increased PKB activity approximately 10-fold and PDE3B phosphorylation and activity ( approximately 4-fold ), but increased PDE4 to the same extent as in F/V cells ... In F/B* cells, IGF-1 had little further effect on PKB and activation/phosphorylation of PDE3B
Tu et al., Cancer Res 2000 (MAP Kinase Signaling System...) : In correlation with activation of PI 3-K, IGF-I also effectively activated the AKT kinase in 8226 and OCI-My5 cells, and IL-6 activated AKT in AF-10 and MH.60 cells
Trümper et al., Ann N Y Acad Sci 2000 : Insulin, IGF-1 , and GLP-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of PKB/Akt ... Insulin, IGF-1 , and GLP-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of PKB/Akt
Tanno et al., Cancer Res 2001 (Neoplasm Invasiveness...) : We demonstrate here that AKT regulates IGF-IR expression in PANC-1 and AsPC-1 cells ... Overexpression of wild-type or constitutively active AKT ( i.e., AKT1 or AKT2 ) also resulted in elevated IGF-IR expression ... Furthermore, AKT induced IGF-IR expression was down-regulated by dominant negative Src or PTEN ... These data provide evidence for a link between AKT signaling and the regulation of IGF-IR expression and demonstrate that active AKT promotes the invasiveness of pancreatic cancer cells through the up-regulation of IGF-IR expression
Sumitomo et al., Cancer Res 2001 (Prostatic Neoplasms) : Incubation of TSU-Pr1 cells with specific kinase inhibitors together with ET-1 or bombesin showed that IGF-IR activation is required for neuropeptide induced Akt phosphorylation, and that neuropeptide induced Akt activation is predominantly mediated by Src and phosphatidylinositol 3-kinase but not by mitogen activated protein kinase or protein kinase C
Wu et al., Oncogene 2001 (Glioblastoma) : Targeted deletion of the N-terminal SH2 domain of SHP-2 severely impaired PDGF- and IGF induced Akt phosphorylation
Klotz et al., J Biol Chem 2002 : In addition, IGF-1 stimulated phosphorylation of uterine Akt and MAPK in both WT and alpha ERKO mice
Varma et al., Cancer Res 2002 (Breast Neoplasms) : Consistent with this suggestion, IGF-I induced phosphorylation of extracellular signal regulated kinase, AKT , and insulin receptor substrate 1 was unaffected by ICI treatment
Adachi et al., Gastroenterology 2002 (Colonic Neoplasms) : It effectively blocked both IGF-I- and IGF-II induced activation of Akt-1
Lee et al., Cancer Gene Ther 2003 (Adenocarcinoma, Bronchiolo-Alveolar...) : Both ad-IGF-IR/950 and ad-IGF-IR/482 effectively blocked IGF-I induced Akt kinase activation
Duplomb et al., Endocrinology 2003 : Confirming this idea, ERK1/2 and AKT/protein kinase B, the kinases necessary for cell proliferation and survival, were activated by IGF-II alone or by the association of IL-6-type cytokines and IGF-II ... Activation of ERK1/2 and AKT by IGF-II thus appears essential to sustain cellular expansion driven by IL-6-type cytokines
Moorehead et al., J Biol Chem 2003 : Transgenic IGF-II expression also increased mammary PTEN protein, leading to reductions in Akt phosphorylation, epithelial proliferation, and mammary morphogenesis
Min et al., Cancer Res 2003 (Pancreatic Neoplasms) : It effectively blocked both IGF-I and IGF-II induced activation of Akt-1
Lu et al., Biochem Biophys Res Commun 2004 (Breast Neoplasms...) : However, IGF-I induced tyrosine-phosphorylation of IGF-I receptor and IRS-I and AKT phosphorylation were unaffected by ErbB2 overexpression
Sivaprasad et al., Endocrinology 2004 (MAP Kinase Signaling System) : In contrast, IGF-I induced Akt activation was maximal between 15 and 90 min and was sustained for 6 h
Tiffin et al., Endocrinology 2004 (MAP Kinase Signaling System) : Akt phosphorylation is not sufficient for insulin-like growth factor stimulated myogenin expression but must be accompanied by down-regulation of mitogen activated protein kinase/extracellular signal regulated kinase phosphorylation
Phornphutkul et al., J Endocrinol 2004 : In contrast, IGF-I mediated Akt activation was unchanged by differentiation, indicating intact upstream IGF-I receptor signaling
Cui et al., J Biol Chem 2005 : In addition, IGF-I activated Akt while inhibiting caspase-3 activation, and these effects were reversed by the PI3K inhibitors LY 294002 and wortmannin, but not by the MEK1 inhibitor PD 98059
Yi et al., J Neurosci 2005 (Diabetic Retinopathy...) : However, IGF1 stimulated Akt phosphorylation was barely detected, and cleaved/activated caspase-3 was significantly elevated in isolated retinas of Irs2-/- mice
Yi et al., Biochem Biophys Res Commun 2005 (Adenocarcinoma...) : These findings suggest that PTEN may inhibit antiapoptotic IGF actions not only by blocking the IGF-IGFR induced Akt activity, but also by regulating expression of components of the IGF system, in particular, upregulation of IGFBP-3, which is known to exert antiproliferative effects through IGF dependent and IGF independent mechanisms in cancer cells
Min et al., Gut 2005 (Neoplasm Invasiveness...) : IGF-Ir/dn blocked Akt-1 activation induced by IGF-I, IGF-II, and des ( 1-3 ) IGF-I, but not by insulin
Brywe et al., Eur J Neurosci 2005 (Hypoxia-Ischemia, Brain) : In conclusion, IGF-I induces activation of Akt during recovery after HI which, in combination with inactivation of GSK3beta, may explain the attenuated activation of caspases and reduction of injury in the immature brain
Remacle-Bonnet et al., Am J Pathol 2005 (Carcinoma...) : However, disruption of rafts by acute cholesterol depletion shifted IGF-IR to non-raft domains, abolished the IGF-I mediated proapoptotic effect, and inhibited the IGF-I dependent IRS-1 and Akt recruitment into and phosphorylation/activation within lipid rafts
Wang et al., Clin Cancer Res 2006 (Carcinoma...) : Blocking IGF-IR blocked Akt phosphorylation and decreased proliferation and microvessel density but increased apoptosis within the tumor xenografts
Wilson et al., J Biol Chem 2006 : We previously identified an autocrine pathway involving production of IGF-II and activation of the IGF-I receptor, phosphatidylinositol 3-kinase, and Akt in myoblast differentiation induced by MyoD in 10T1/2 mesenchymal stem cells and found that blocking this pathway prevented differentiation ( Wilson, E. M., Hsieh, M. M., and Rotwein, P. ( 2003 ) J. Biol. Chem. 278, 41109-41113 )
Wu et al., Development 2006 : Kermit 2/XGIPC functions downstream of IGF in eye formation and is required for maintaining IGF induced AKT activation
Desbois-Mouthon et al., Int J Cancer 2006 (Carcinoma, Hepatocellular...) : However, while gefitinib blocked Akt activation by EGF, it had no effect on Akt activation by IGF2 and did not cause apoptosis by its own
Azar et al., Can J Physiol Pharmacol 2006 : Activation of insulin-like growth factor type-1 receptor is required for H2O2 induced PKB phosphorylation in vascular smooth muscle cells
Tanno et al., Clin Cancer Res 2006 (Adrenal Gland Neoplasms...) : As expected, NVP-AEW541 inhibited IGF-II mediated stimulation of IGF-IR and Akt
Tanaka et al., Cancer Res 2006 (Anoxia...) : Treating the HCC cells with IGF-II or epidermal growth factor (EGF) up-regulated both phospho-Akt and HIF-1alpha, whereas inhibition of IGF-II or EGF signaling down-regulated them both, suggesting that IGF-II and EGF can, at least in part, mediate the activation of Akt and HIF-1alpha ... However, Akt was not activated by IGF-II or EGF in the HIF-1alpha knockdown cells, indicating that expression of the HIF-1 target genes is necessary for the Akt activation
Ogura et al., J Toxicol Sci 2007 : After induction of differentiation in the presence of 1 microM simvastatin for 2 days, IGF-1 induced activation of ERK1/2 and Akt was significantly decreased
Alexia et al., Ann N Y Acad Sci 2006 (Carcinoma, Hepatocellular) : Drug induced apoptosis was reversed by IGF-I and this effect was ( i ) dependent on Akt-1 and -2 phosphorylation and ( ii ) accompanied by the inhibition of initiator caspase-9 activity, suggesting that IGF-IR signaling interferes with mitochondria dependent apoptosis
Borowiec et al., J Cell Physiol 2007 (Breast Neoplasms...) : In MCF-7 cells, IGF-1 rapidly stimulated Akt phosphorylation, whereas IGF-1 had little stimulating effect on Erk 1/2 which seems to be constitutively activated
Levitt et al., Cancer Lett 2007 (Prostatic Neoplasms) : The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells
Knowlden et al., Breast Cancer Res Treat 2008 (Breast Neoplasms...) : Furthermore, gefitinib significantly enhances IGF-II mediated phosphorylation of IRS-1 Y612 and AKT in Tam-R cells
Salani et al., Endocrinology 2008 : These results demonstrate that : 1 ) Cav-1 down-regulation negatively affects IGF-IR tyrosine phosphorylation ; 2 ) this effect causes a reduced activation of insulin receptor substrate-1, Shc, and Akt ; and 3 ) Cav-1 is involved in IGF-IR antiapoptotic signaling after serum deprivation
Walenkamp et al., J Clin Endocrinol Metab 2008 (Chromosome Deletion...) : IGF-I binding and type 1 IGF receptor protein expression as well as activation of type 1 IGF receptor autophosphorylation and protein kinase B/Akt by IGF-I tended to be lower, but this did not reach statistical significance
Avram et al., Cell Physiol Biochem 2008 : However, IGF-1 mediated stimulation of PKB phosphorylation was not affected by dexa, but ERK phosphorylation was reduced
Carter et al., Acta Neuropathol 2008 (Brain Neoplasms...) : Aspartyl (asparaginyl)-beta-hydroxylase ( AAH ) is a mediator of neuronal motility, and stimulated by insulin and IGF activation of PI3 kinase-Akt , or inhibition of GSK-3beta
Codina et al., Gen Comp Endocrinol 2008 : Metabolic and mitogenic effects of IGF-II in rainbow trout ( Oncorhynchus mykiss ) myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways
Piao et al., Mol Cancer Ther 2008 (Gastrointestinal Neoplasms) : NVP-AEW541 blocked autophosphorylation of IGF-IR and both Akt and extracellular signal regulated kinase activation by IGF but not by insulin
Matthews et al., Endocrinology 2008 : However, in MF ( -/- ) cells, IGF-I stimulated phosphorylation of Akt was reduced despite up-regulated Akt levels
Moylan et al., Am J Physiol Cell Physiol 2008 : TNF increases AKT phosphorylation ( +50 % ) and stimulation of AKT with IGF does not prevent TNF induction of atrogin mRNA
Buck et al., Cancer Res 2008 (MAP Kinase Signaling System...) : We find for epithelial, but not for mesenchymal-like, tumor cells that Akt is controlled cooperatively by EGFR and IGF-IR
Thomas et al., Prostate 2009 (Prostatic Neoplasms) : Additionally, inhibition of IGF-2 activity markedly attenuated the serum deprivation mediated increase in IGF-IR and Akt activation, HIF-1alpha expression, and also its own transcription, suggesting autocrine regulation of HIF-1alpha expression via IGF-2 ... Cross-talk between IGF-2/ IGF-IR system and PI3K-Akt pathway was further demonstrated by findings wherein IGF-IR suppression inhibited Akt activation, and IGF-IR activation was inhibited following PI3K inhibition
Cao et al., Science signaling 2009 : Loss of Galpha ( i1 ) and Galpha ( i3 ) severely impaired the activation of Akt and of p70 S6 kinase and 4E-BP1, downstream targets of mTORC1, in response to EGF, heparin binding EGF-like growth factor, and transforming growth factor alpha, but not insulin, insulin-like growth factor , or platelet derived growth factor
Rowzee et al., Endocrinology 2009 : Although approximately 40 % of IR transcripts were the IGF-II-sensitive IR-A isoform, IGF-II failed to stimulate IR phosphorylation, and an IGF-1R-specific blocking antibody completely abrogated IGF-II mediated Akt phosphorylation in the virgin MECs
Yin et al., J Biol Chem 2009 : In normal human chondrocytes, IGF-I initiated a strong and sustained phosphorylation of IRS-1 ( Tyr-612 ) and Akt ( Ser-473 ) and transient ERK phosphorylation
Sunters et al., J Biol Chem 2010 : Strain related IGF-IR activation of AKT requires estrogen receptor alpha (ERalpha) with which IGF-1R physically associates
Wang et al., Invest Ophthalmol Vis Sci 2010 : Rat lens epithelial explants were used to compare the ability of vitreous, IGF-1 , PDGF-A, EGF, and FGF-2 to stimulate the phosphorylation of ERK1/2 and Akt leading to fiber differentiation, in the presence or absence of selective receptor tyrosine kinase ( RTK ) inhibitors
Jung et al., J Med Food 2010 (Urinary Bladder Neoplasms) : These results indicate that the inhibition of IGF-IR signaling and the activation of Akt and ERK-1/2 contributed to decreased cell proliferation and increased apoptosis in TSU-Pr1 cells treated with t10c12
Lee et al., Cell Death Differ 2010 : Furthermore, myogenic activity was highly enhanced with increased IGF induced Akt activation in the satellite cells of TRIM72 ( -/- ) mice, compared to those of TRIM72+/+ mice
Ren et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : Hypoxia suppresses basal and IGF induced Akt-mTOR and p38 activity, whereas it enhances and prolongs IGF induced Erk1/2 activation in a HIF-1 dependent fashion
Zhang et al., Neurochem Res 2011 : Furthermore, IGF-1 increased the phosphorylation of Akt and ERK1/2
Peirce et al., Cancer Chemother Pharmacol 2011 (Neuroblastoma) : SF1126 blocks MDM2 activation, IGF-1 induced activation of Akt , and the upregulation of survivin induced by IGF-1
Xie et al., J Steroid Biochem Mol Biol 2011 (Carcinoma...) : In parallel, IGF-II increases phosphorylation of AKT and p70S6K, while metformin increases AMPK phosphorylation and decreases p70S6K phosphorylation
Li et al., Cancer 2011 (Neovascularization, Pathologic...) : IGF-IR/dn reduced VEGF expression, reduced the activation of both protein kinase B ( Akt ) and mitogen activated protein kinase ( MAPK ), and reduced vascular formation, indicating that IGF-IR/dn inhibited tumor growth in mice by inhibiting both angiogenesis and lymphangiogenesis
Kyathanahalli et al., Biochem Pharmacol 2011 : Herein, we investigated the putative regulatory roles of protein farnesylation in cell survival signaling pathways in insulin secreting INS 832/13 cells and normal rodent islets, specifically at the level of protein kinase-B/Akt phosphorylation induced by insulin-like growth factor [IGF-1 ]
Madhala-Levy et al., J Cell Physiol 2012 (MAP Kinase Signaling System) : In cultures derived from Smo ( mut ) ( MCre ; Smo ( flox/flox ) ) mice lacking Smo expression specifically in hindlimb muscles, IGF-I induced Akt and p42/44 phosphorylation was significantly reduced compared to IGF-I 's effect on Smo ( cont ) cells
Capp et al., Eur J Obstet Gynecol Reprod Biol 2011 : Insulin, IGF I and IGF II lead to changes in their receptor gene expression and induced Akt phosphorylation in ESC
Fernandez-L et al., Oncogene 2012 (Cerebellar Neoplasms...) : Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2 mediated Akt activation
Fox et al., Cancer Res 2011 (Adenocarcinoma...) : Inhibition of InsR and IGF-IR with the dual tyrosine kinase inhibitor OSI-906 prevented the emergence of hormone independent cells and tumors in vivo, inhibited parental and LTED cell growth and PI3K/AKT signaling, and suppressed growth of established MCF-7 xenografts in ovariectomized mice, whereas treatment with the neutralizing IGF-IR monoclonal antibody MAB391 was ineffective
Akundi et al., Neurobiol Dis 2012 : Moreover, IGF-1 induced Akt phosphorylation is impaired in primary cortical neurons from PINK1-deficient mice
Ohashi et al., Cancer Sci 2012 (Biliary Tract Neoplasms) : BMS-536924 blocked autophosphorylation of IGF-IR and both Akt and ERK activation by both IGF-I and insulin
Zhang et al., J Clin Endocrinol Metab 2012 (Graves Ophthalmopathy) : Surprisingly, IGF-I alone did not increase HAS2 levels, despite significantly increasing the ratio of phosphorylated to total Akt ; furthermore, an Akt inhibitor increased orbital ( but not sc ) HAS2 transcripts
Bid et al., Mol Cancer Ther 2012 (Neovascularization, Pathologic...) : SCH717454 blocked IGF-1 stimulated but not IGF-2 stimulated phosphorylation of Akt in sarcoma cells
Kent et al., Int J Dev Biol 2012 : Disruption of IGF2 did not affect AKT expression or activation
Appleman et al., Mol Cancer Res 2012 : Interestingly, we find that activation of PI3K/AKT signaling occurs downstream of MAP-ERK kinase ( MEK ), and is dependent on the autocrine activation of the insulin-like growth factor (IGF) receptor ( IGF1R ) by IGF2
Jiao et al., Mol Cell Biochem 2013 (MAP Kinase Signaling System) : In addition, Akt , Erk1/2 MAPK, and p38 MAPK pathways were also involved in the regulation of basal levels of IGF-I and IGF-II genes during myogenesis
Willey et al., Int J Radiat Biol 2013 : Both doses decreased IGF induced Akt activation and IGF-1 receptor phosphorylation
Fujita et al., J Biol Chem 2013 : Inhibitors of IGF1R, Src, AKT , and ERK1/2 did not suppress avß3-IGF-IGF1R ternary complex formation, suggesting that activation of these kinases are not required for ternary complex formation
Kessler et al., Am J Physiol Gastrointest Liver Physiol 2013 (Carcinoma, Hepatocellular...) : Still, p62 transgenic livers do not show liver cell damage but exhibit a pronounced induction of Igf2 and activation of the downstream survival kinase AKT
Bid et al., Clin Cancer Res 2013 (Disease Models, Animal...) : The IGF ligand binding antibody MEDI-573 suppressed Akt phosphorylation induced by exogenous IGF-I and IGF-2 in sarcoma cells
Arroba et al., Invest Ophthalmol Vis Sci 2013 (Disease Models, Animal...) : IGF-IR mediated Akt signaling was evaluated in IGF-I stimulated retinal explants
Dong et al., Am J Physiol Endocrinol Metab 2013 (Fibrosis) : Using immunoprecipitation assay, we found an interaction between p-Akt or Akt with Smad3 in wild-type mouse muscles and in C2C12 myoblasts ; importantly, IGF-I increased p-Akt and Smad3 interaction, whereas TGF-ß1 decreased it ... Therefore, in muscles of IGF-IR ( +/- ) mice, the reduction in IGF-IR reduces p-Akt , allowing for dissociation and nuclear translocation of Smad3 to enhance the TGF-ß1 signaling pathway, leading to fibrosis
Ou et al., PloS one 2013 : We found that IGF can activate IGFR and downstream AKT signaling activities in all the HCC cells tested, but the growth stimulating effect of IGF was most prominent in Hep3B cells ... NVP-AEW541 can abrogate IGF induced activation of IGFR and AKT signaling in HCC cells
Huang et al., Stem cell research 2013 (Osteoporosis) : The mechanism dissection studies revealed that AR deficiency suppressed osteogenesis related genes to inhibit osteoblast differentiation from BMSCs. Knockout of AR promoted adipogenesis of BMSCs via Akt activation through IGFBP3 mediated IGF signaling, and the 5 ' promoter assay and chromatin immunoprecipitation assays further proved that AR could modulate IGFBP3 expression at the transcriptional level
Cichy et al., J Biol Chem 1998 : Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor binding protein-1 gene expression through a conserved insulin response sequence ... Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor binding protein-1 gene expression through a conserved insulin response sequence
Hayashi et al., J Biol Chem 1998 : In cultured cells, IGF-I specifically activated phosphatidylinositol 3-kinase ( PI3-kinase ) and its downstream target, protein kinase B , but not mitogen activated protein kinases