Gene interactions and pathways from curated databases and text-mining

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AKT1 — IGF1R

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Nagasawa et al., Biochem J 2005 : EP2 stimulation failed to inhibit tyrosine phosphorylation either of IGF-I receptor or IRS-1 ( insulin receptor substrate-1 ), or activation of phosphoinositide 3-kinase or Akt in response to IGF-I, but potently and dose-dependently inhibited IGF-I induced activation of cellular Rac activity and membrane ruffling
Li et al., Am J Physiol Heart Circ Physiol 2006 : IGF-1R activation increased Akt phosphorylation and soluble FasL expression, and these effects were completely blocked by coincubating hVSMC with ANG II
O'Reilly et al., Cancer Res 2006 : IGF-I receptor inhibition prevents rapamycin induced Akt activation and sensitizes tumor cells to inhibition of mTOR
Mehdi et al., Biochemistry 2006 : Moreover, efficient reduction of the level of IGF-1R protein expression by antisense oligonucleotides ( ASO ) attenuated BMOV induced PKB phosphorylation ... Taken together, these data suggest that IGF-1R and PKCdelta are required to stimulate PKB phosphorylation in response to BMOV in HepG2 cells and provide new insights into the molecular mechanism by which this compound exerts its insulinomimetic effects
Patel et al., Int J Cancer 2008 (Colorectal Neoplasms) : These changes were associated with decreased expression and activation ( tyrosine phosphorylation ) of EGFR, HER-2, HER-3 ( 72-100 % ) and IGF-1R ( 67 % ) as well as their downstream effectors such as Akt and cycloxygenase-2 ( 51-97 % )
Duarte et al., Biochim Biophys Acta 2008 : Thus, insulin mediated activation of IR/IGF-1R stimulates PI-3K/Akt and inhibits GSK-3beta signaling pathways, modifying neuronal antioxidant defense-, glucose metabolism- and anti-apoptotic associated protein synthesis
Papageorgiou et al., Mol Med 2008 (Prostatic Neoplasms) : Because the IGF-1R signaling is probably the most important host tissue ( bone ) metastasis microenvironment related survival signaling for prostate cancer cells, we conclude that rosiglitazone effects on IGF-1R mediated activation of ERK1/2 and AKT could have clinical implications for the management of androgen ablation-refractory and chemotherapy-resistant advanced prostate cancer with bone metastasis
Hu et al., Cancer Res 2008 (Carcinoma...) : IGF1R activation by ligand exposure in growth factor deprived cells induces Akt activation in the FET, CBS, and GEO colon cancer cell lines ... On the other hand, a small-molecule IGF1R inhibitor, PQIP, blocked Akt phosphorylation
Engberding et al., Arterioscler Thromb Vasc Biol 2009 (Diabetes Mellitus, Type 2...) : IGF1R overexpression in VSMCs impaired insulin induced Akt phosphorylation
Chu et al., Chin J Physiol 2009 (Heart Diseases) : Western blots and TUNEL assay revealed that in the presence of IGF1R , exogenous IGF-II acts, like IGF-I, would increase phospho-Akt through IGF1R, but does not affect the caspase 3 activation and apoptotic induction in H9c2 cardiomyoblast cells
Ester et al., J Clin Endocrinol Metab 2009 (Chromosome Deletion) : Functional studies in skin fibroblast cultures demonstrated similar levels of IGF1R autophosphorylation and a reduced activation of protein kinase B/Akt upon a challenge with IGF-I in comparison with controls ... Functional studies in skin fibroblast cultures demonstrated similar levels of IGF1R autophosphorylation and a reduced activation of protein kinase B/Akt upon a challenge with IGF-I in comparison with controls
Pandey et al., J Biol Inorg Chem 2010 : Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+ induced ERK1/2 and PKB phosphorylation
Chapuis et al., Haematologica 2010 (Blast Crisis...) : Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia : therapeutic value of neutralizing anti-IGF-1R antibody ... Specific inhibition of IGF-1R signaling with neutralizing anti-IGF-1R strongly inhibited the constitutive phosphorylation of both IGF-1R and Akt in 70 % of the PI3K activated samples
Huang et al., Clin Cancer Res 2010 (Ovarian Neoplasms) : Taxol induced AKT phosphorylation required IGF1R tyrosine kinase activity and was associated with upregulation of IGF2
Leclerc et al., Journal of molecular signaling 2010 : We determined that activation of P-Akt ( Thr308 ) was mediated by AMPK induced IGF-1R activation via phosphorylation of the insulin receptor substrate-1 (IRS-1) at Ser794 ... Inhibition of IGF-1R signaling using the tyrosine kinase inhibitor HNMPA ( AM ) 3 resulted in significant decrease in P-IRS-1 ( Ser794 ) and P-Akt ( Thr308 )
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt , mTOR, p70S6K, 4EBP and cyclin D1
Qin et al., J Biochem 2011 : Our data here show that hyperactive AKT leads to the decrease of IGF1R at the transcriptional level, which could be partly restored by phosphatidylinositol-3 kinase (PI3K) inhibitors including wortmannin and LY294002 ... mTOR as a main downstream target of AKT is not involved in the AKT mediated down-regulation of IGF1R
Brevet et al., J Thorac Oncol 2011 (Mesothelioma...) : MET, EGFR, and insulin-like growth factor 1 receptor were the main RTKs activated after mTOR inhibition and contributed to AKT feedback activation
Jameson et al., Mol Cancer Ther 2011 (Carcinoma, Squamous Cell...) : In both the cell lines, IGF1R induced Erk, but not Akt , activation was eliminated by gefitinib
He et al., Ann Oncol 2012 (Breast Neoplasms...) : Human epidermal growth factor receptor ( HER2 ), insulin receptor and IGF-I receptor involve the same PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
Lin et al., EMBO Mol Med 2012 (Adenocarcinoma...) : Trop-2 could attenuate IGF-1R signalling mediated AKT/ß-catenin and ERK activation through a direct binding of IGF1
Fagan et al., Cancer Res 2012 (Breast Neoplasms) : An IGF1R tyrosine kinase inhibitor, AEW541, with equal potency for the IGF1R and IR, inhibited IGF-I-, IGF-II-, and insulin stimulated Akt phosphorylation, proliferation, and anchorage independent growth in parental cells
Estañ et al., Biochem Pharmacol 2012 (Leukemia) : In summary 2-DG elicits IGF-1R mediated AMPK inactivation and Akt and ERK activation, which facilitates or restrain apoptosis, respectively
Fujita et al., J Biol Chem 2013 : Inhibitors of IGF1R, Src, AKT , and ERK1/2 did not suppress avß3-IGF-IGF1R ternary complex formation, suggesting that activation of these kinases are not required for ternary complex formation
Shu et al., Cellular oncology (Dordrecht) 2013 (Carcinoma, Hepatocellular...) : Klotho is a tumor suppressor that, through the regulation of IGF-1R phosphorylation and subsequent activation of downstream Akt-p70S6K and ERK signaling, regulates HCC tumor cell proliferation, apoptosis, autophagy and invasion
Xie et al., Cancer cell international 2013 : Klotho is a tumor suppressor in gastric cancer, which regulates IGF-1R phosphorylation and the subsequent activation of IRS-1/PI3K/Akt/mTOR signaling, tumor cell proliferation, apoptosis, and autophagy
Chen et al., Cancer Discov 2013 (Carcinoma, Non-Small-Cell Lung...) : The mechanistic basis for this effect seems to be an increased baseline activation of IGF1R mediated activation of AKT in cells that express oncogenic KRAS