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IGF1 — SIRT1
Text-mined interactions from Literome
Li et al., Cell Metab 2008
:
SirT1 inhibition
reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons ... SirT1 inhibition increased acetylation and decreased phosphorylation of IRS-2 ; it also reduced activation of the Ras/ERK1/2 pathway, suggesting that
SirT1 may
enhance IGF-I signaling in part by deacetylating IRS-2
Saini et al., Exp Physiol 2012
:
Likewise,
Sirt1 expression was elevated following 10 ng ml(-1) TNF-a administration, but was
reduced ( ~30 % ; P < 0.05 ) in the presence of
IGF-I