Gene interactions and pathways from curated databases and text-mining

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IGF1 — SIRT1

Text-mined interactions from Literome

Li et al., Cell Metab 2008 : SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons ... SirT1 inhibition increased acetylation and decreased phosphorylation of IRS-2 ; it also reduced activation of the Ras/ERK1/2 pathway, suggesting that SirT1 may enhance IGF-I signaling in part by deacetylating IRS-2
Saini et al., Exp Physiol 2012 : Likewise, Sirt1 expression was elevated following 10 ng ml(-1) TNF-a administration, but was reduced ( ~30 % ; P < 0.05 ) in the presence of IGF-I