Gene interactions and pathways from curated databases and text-mining

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CREB1 — IGF1

Text-mined interactions from Literome

Bruning et al., Proc Natl Acad Sci U S A 2000 : Thus Rsk-2 is required for growth factor stimulated expression of c-Fos and transcriptional activation of Elk-1 and the serum response factor, but not for activation of CREB or the mitogen activated protein kinase pathway in response to PDGF and IGF-1 stimulation
Grimes et al., J Neurochem 2001 : Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in CREB DNA binding activity induced by epidermal growth factor, insulin-like growth factor-1 , forskolin, and cyclic AMP
Mehrhof et al., Circulation 2001 : IGF-I also induced phosphorylation of cAMP response element binding protein ( CREB ) in a PI3K- and MEK1 dependent manner
Liu et al., Endocrinology 2002 : IGF-I increased CREB phosphorylation at a concentration as low as 10 ng/ml, and this effect was inhibited by H89, a PKA inhibitor, and PD98059, a MAPK kinase inhibitor ... Consistent with the effect of IGF-I on CREB phosphorylation, IGF-I increased the transcriptional activity of CREB , although it had no effect on CREB binding to DNA ... Consistent with the effect of IGF-I on CREB phosphorylation, IGF-I increased the transcriptional activity of CREB , although it had no effect on CREB binding to DNA
Zheng et al., J Biol Chem 2002 : Gel mobility shift assay using a double stranded oligonucleotide for the CREB site in the promoter region, and competition experiments with excess unlabeled or mutated promoter oligonucleotide, and unlabeled consensus CREB oligonucleotide demonstrated that IGF-1 induces CREB binding to the DHPR alpha ( 1S ) promoter
Moorehead et al., Oncogene 2003 (Adenocarcinoma, Bronchiolo-Alveolar...) : Moreover, IGF-II induced proliferation and CREB phosphorylation in human lung cancer cell lines, suggesting that IGF-II and CREB also contribute to the growth of human lung tumors
Zhong et al., J Neurosci Res 2004 : We demonstrated also that high K ( + ) -induced depolarization, but not IGF-1 , increased phosphorylation of cAMP-response element binding protein ( CREB ) and protein synthesis, both of which can be blocked by UO126
Zheng et al., J Membr Biol 2004 : IGF-1 significantly increased CaM kinase and calcineurin activity and the cellular levels of phosphorylated CREB in a time dependent manner ... These results support the conclusion that IGF-1 controls CREB phosphorylation by activating a phosphorylation and dephosphorylation cascade, which ultimately modulates the DHPRalpha ( 1S ) gene transcription
Fernández et al., J Mol Endocrinol 2005 : IGF-I and vasoactive intestinal peptide (VIP) regulate cAMP-response element binding protein ( CREB ) -dependent transcription via the mitogen activated protein kinase ( MAPK ) pathway in pituitary cells : requirement of Rap1 ... IGF-I induced cAMP-response element ( CRE ) -binding protein ( CREB ) phosphorylation through the Ras-MAPK pathway, whereas VIP phosphorylated CREB directly via PKA ... In summary, we showed that IGF-I and VIP stimulated MAPK activity and the phosphorylation of CREB in pituitary cells
Maldonado et al., Biochem Biophys Res Commun 2005 (Calcium Signaling) : Because in these cells IGF-1 induces intracellular Ca ( 2+ ) increase, we assessed whether the cyclic AMP response element binding protein ( CREB ) is activated by IGF-1 through Ca ( 2+ ) -dependent signalling pathways ... In cultured cardiac myocytes, IGF-1 induced phosphorylation ( 6.5 +/- 1.0-fold at 5 min ), nuclear translocation ( 30 min post-stimulus ) and DNA binding activity of CREB ... In cultured cardiac myocytes, IGF-1 induced phosphorylation ( 6.5 +/- 1.0-fold at 5 min ), nuclear translocation ( 30 min post-stimulus ) and DNA binding activity of CREB ... IGF-1 induced CREB phosphorylation was mediated by MEK1/ERK, PI3-K, p38-MAPK, as well as Ca ( 2+ ) /calmodulin kinase and calcineurin ... Exposure of cardiac myocytes to hyperosmotic stress ( sorbitol 600 mOsm ) decreased IGF-1 induced CREB activation Moreover, overexpression of a dominant negative CREB abolished the anti-apoptotic effects of IGF-1
Willaime-Morawek et al., Brain Res Mol Brain Res 2005 : Analysis of the signal transduction pathways revealed that IGF-I induces CREB phosphorylation via PI-3K and ERK, whereas simultaneous ceramide and IGF-I treatment decreases CREB phosphorylation
Zheng et al., BMC neuroscience 2006 (MAP Kinase Signaling System) : These data suggest that IGF-1 induced the activation of Akt and CREB using distinct pathways in PC12 cells
Singh et al., International journal of biological sciences 2007 : IGF-1 increases the cyclic AMP-responsive element ( CRE ) binding transcription factor CREB phosphorylation at Ser 133 and CRE binding activity in mesangial cells, which parallels cyclin D1 and fibronectin expressions
Ishida et al., Am J Physiol Endocrinol Metab 2007 : Insulin-like growth factor I (IGF-I) , a potent mitogen in lactotrophs, did not affect intracellular cAMP concentrations but transiently increased lactotroph CREB phosphorylation
Genua et al., Cancer Res 2009 (Prostatic Neoplasms) : In conclusion, we describe a novel mechanism of IGF-IR up-regulation and promoter activity by CREB activation, induced by sex steroids, through a nongenotropic signaling
Yan et al., Dev Neurobiol 2013 : Consistently, Western immunoblot analysis demonstrated that IGF-I induced CREB ( CRE binding protein ) phosphorylation, while ablation of CREB expression with small interfering RNAs ( siRNA ) blocked IGF-I actions on cyclin D1 mRNA expression and cell proliferation ... Additionally, IGF-I stimulated CREB phosphorylation was blunted by the MAP kinase inhibitor, PD98059, but not by the PI3 kinase inhibitor, wortmannin ... Additionally, IGF-I stimulated CREB phosphorylation was blunted by the MAP kinase inhibitor, PD98059, but not by the PI3 kinase inhibitor, wortmannin ... ChIP assays revealed that IGF-1 increased the association of CREB with the cyclin D1 promoter
Liu et al., J Neurochem 2013 : microRNA-181a is involved in insulin-like growth factor-1 mediated regulation of the transcription factor CREB1 ... These suggest that miR-181a is involved in IGF-1 regulated CREB1 expression by targeting its mRNA 3'UTR ... Repressed expression of miR-181a is involved in IGF-1 mediated up-regulation of CREB1 in vivo and in vitro
Pugazhenthi et al., J Biol Chem 1999 : CREB phosphorylation at serine 133 and its transcriptional activation as measured by a CREB-specific Gal4-CREB reporter and the neuroendocrine-specific gene chromogranin A was induced 2-3.3-fold by insulin-like growth factor (IGF)-I ... Constitutively active and dominant negative regulators of the Ras and PI 3-kinase pathways confirmed the contribution of these pathways for CREB regulation by IGF-I