Gene interactions and pathways from curated databases and text-mining

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IFNG — NOTCH4

Text-mined interactions from Literome

Weijzen et al., J Immunol 2002 : Furthermore, coculture of DCs with cells expressing Notch ligand Jagged-1 induced up-regulation of maturation markers, IL-12 production, T cell proliferative responses, and IFN-gamma production
Palaga et al., J Immunol 2003 : TCR mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells ... Inhibition of Notch activation dramatically decreases T cell proliferation in both CD4 and CD8 cells and blocks both NF-kappaB activity and IFN-gamma production in peripheral T cells
Wong et al., J Clin Invest 2003 : Ligation of Notch on splenic CD8+ cells results in a dramatic decrease in IFN-gamma with a concomitant enhancement of IL-10 production, suggesting that Notch signaling can alter the differentiation potential of CD8+ cells
Monsalve et al., J Immunol 2006 (Inflammation) : Furthermore, Raw 264.7 Notch-IC stable transfectants increased STAT1 dependent transcription in response to IFN-gamma , leading to higher expression of IFN regulatory factor-1, suppressor of cytokine signaling-1, ICAM-1, and MHC class II proteins