Gene interactions and pathways from curated databases and text-mining

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IFNG — IGF1

Text-mined interactions from Literome

Tu et al., Pediatr Res 1999 : IGF-I increases interferon-gamma and IL-6 mRNA expression and protein production in neonatal mononuclear cells
Shalita-Chesner et al., Mol Cell Endocrinol 2001 : This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein, and with inhibition of IGF-l-R promoter activity, suggesting that TNF-alpha and IFN-gamma affect IGF-l-R gene expression at the transcriptional level
Anwar et al., Circulation 2002 (Arteriosclerosis) : IL-1beta, IL-6, and IFN-gamma did not regulate IGF-1 , IGF-1 receptor (R), or IGF binding proteins ( IGFBPs ) ... IL-1beta, IL-6, and IFN-gamma did not regulate IGF-1, IGF-1 receptor (R), or IGF binding proteins ( IGFBPs )
Bernabei et al., Blood 2003 : These data indicate that IGF-1 plays a critical role in the desensitization of IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization
Hwa et al., J Biol Chem 2004 : Transcriptional regulation of insulin-like growth factor-I by interferon-gamma requires STAT-5b
Shalita-Chesner et al., J Pediatr Endocrinol 2004 (Bone Neoplasms...) : The potential involvement of STAT proteins in transcriptional regulation of the IGF-IR gene by IFN-gamma was addressed by transient coexpression of vectors encoding STAT1 and STAT5b, together with an IGF-IR promoter luciferase reporter, in the osteosarcoma derived cell line Saos-2
Sato et al., Int J Oncol 2006 (Carcinoma, Renal Cell...) : In KU19-20 cells, cell proliferation and survivin expression were significantly induced by IGF-1 , whereas they were inhibited by a novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin ( DHMEQ ) and IFN-gamma
Jia et al., Am J Physiol Heart Circ Physiol 2007 (Carotid Artery Diseases...) : Here we assessed the expression of IGF-I receptor (IGF-IR) in atherosclerotic plaques and in plaque VSMCs of asymptomatic and symptomatic patients with carotid stenosis and examined the effect of IGF-I, IL-12, and IFN-gamma on the expression of IGF-IR and IGF binding protein (IGFBP)-3 in plaque VSMCs
Hu et al., Mol Hum Reprod 2008 : IFN-gamma relatively increased IGF-1 and -2 secretion
Arkins et al., Mol Endocrinol 1995 : Interferon-gamma inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level
Taniguchi et al., Blood 1997 : Although some inhibitory cytokines including IFNgamma have been shown to downregulate growth factor receptors, the effect of IFNgamma on SCF, EP, and IGF-I receptors of human erythroid progenitor cells has not been defined