Gene interactions and pathways from curated databases and text-mining

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CREB1 — IFNG

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hamada et al., Toxicology 2000 : However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with rMu-IFN-gamma + Be increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of AP-1 and CREB at 15 h, however, only Jun B was increased
Samten et al., J Immunol 2002 (Tuberculosis) : These data suggest that reduced expression of CREB nuclear proteins in tuberculosis patients results in decreased IFN-gamma promoter activity and reduced IFN-gamma production
Frissora et al., Eur J Immunol 2003 : IFN-gamma mediated inhibition of antigen receptor induced B cell proliferation and CREB-1 binding activity requires STAT-1 transcription factor ... Recombinant IFN-gamma inhibited the BCR induced CREB-1 DNA binding activity and cell proliferation in B cells from signal transducer and activator of transcription-1 ( STAT-1 ) ( +/+ ), but not STAT-1 ( -/- ) mice
Liu et al., J Interferon Cytokine Res 2004 : Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma
Hu et al., Immunity 2006 (Arthritis...) : IFN-gamma suppressed the activity of CREB and AP-1, transcription factors that induce IL-10 expression and are regulated in part by MAPKs and GSK3
Chiappara et al., Allergy 2007 (Asthma...) : Incubation of PBMC in vitro, with fluticasone propionate, decreased the p-CREB expression induced by cytokine activation ( interferon-gamma , tumor necrosis factor-alpha )
Gilchrist et al., Immunology 2008 : IFN-gamma inhibited PMA induced cAMP response element binding protein ( CREB ) phosphorylation and DNA binding activity
Kim et al., J Leukoc Biol 2008 : IFN-gamma caused phosphorylation of CREB, and overexpression of CREB increased IFN-gamma induced BAFF promoter activity
Samten et al., J Immunol 2008 : CREB , ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
Liu et al., Clinical and vaccine immunology : CVI 2010 (Latent Tuberculosis) : These results suggested that CREB could promote the transcription and production of IFN-gamma through binding with the IFN-gamma proximal promoter, but the regulatory role of CREB was decreased in tuberculosis patients owing to diminished expression of CREB proteins, which in turn reduced the IFN-gamma production