Gene interactions and pathways from curated databases and text-mining

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CASP5 — IFNB1

Text-mined interactions from Literome

Scheel-Toellner et al., Eur J Immunol 1999 : IFN-beta also inhibited caspase 3 and the proteolytic activation of PKC-delta
Morrison et al., Oncogene 2002 (Ovarian Neoplasms) : Both IFN-beta and radiation induced caspase 8
Saito et al., J Neurooncol 2004 (Brain Neoplasms...) : Collectively, these findings indicate that IFN-beta induced apoptosis in human glioma cells through activation of caspase-7 and activation of DNase-gamma
Takada et al., Exp Cell Res 2005 (Lymphoma, B-Cell) : The IFN-beta induced up-regulation of CD95 together with caspase-8 activation was also abrogated in the dnJNK1 cells while it was further enhanced in the MKK7-JNK1 cells
Zhou et al., J Interferon Cytokine Res 2008 (Leukemia) : Consistent with these results, treatment with IFN-gamma, but not IFN-alpha or IFN-beta , induced the release of cytochrome c, activation of caspase-3 , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ), a well characterized caspase-3 substrate
Kawaguchi et al., Int J Cancer 2009 (Prostatic Neoplasms) : Produced IFN-alpha and -beta enhanced caspase 8 expression via Janus kinases/Signal Transducers and Activators of Transcription pathway, activated caspase 3 and induced apoptosis in cancer cells
Yen et al., Blood 2009 (Inflammation...) : Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation
Santic et al., Cell Microbiol 2010 (Tularemia) : Initial sensing of F. tularensis in the cytosol triggers IRF-3 dependent IFN-beta secretion, type I IFNR dependent signalling, activation of the inflammasome mediated by caspase-1 , and a pro-inflammatory response, which is suppressed by triggering of SHIP
Kamiya et al., J Interferon Cytokine Res 2010 (Melanoma) : To characterize the signaling pathway involved in IFN-beta induced apoptosis, we analyzed the biological effects of IFN-beta on the cell death and caspase activation of melanoma cells ... IFN-sensitive cell lines, MM418, SK-mel-23, and SK-mel-118, showed increased apoptotic populations correlated with the activation of caspase-2 and caspase-3 by IFN-beta