◀ Back to AKT1

AKT1 — IFI27

Text-mined interactions from Literome

Pavelić et al., J Mol Med (Berl) 2001 (Body Weight...) : In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B ( c-Akt ), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines
Schönherr et al., J Biol Chem 2001 : Involvement of Akt/protein kinase B in up-regulation of p21 ( WAF1/CIP1 ) but not p27 ( KIP1 )
Dan et al., J Biol Chem 2002 : Akt also inhibits tuberin mediated degradation of p27 ( kip1 ), thereby promoting CDK2 activity and cellular proliferation
Shin et al., Nat Med 2002 (Breast Neoplasms...) : We have shown a novel mechanism of Akt mediated regulation of the CDK inhibitor p27 ( kip1 ) ... These data indicate that Akt may contribute to tumor-cell proliferation by phosphorylation and cytosolic retention of p27 , thus relieving CDK2 from p27 induced inhibition
Liang et al., Nat Med 2002 (Breast Neoplasms) : Thus, we show a novel mechanism whereby Akt impairs p27 function that is associated with an aggressive phenotype in human breast cancer
Viglietto et al., Nat Med 2002 (Breast Neoplasms) : Conversely, the p27 ( kip1 ) -T157A mutant accumulates in cell nuclei and Akt does not affect p27 ( kip1 ) -T157A mediated cell cycle arrest
Narita et al., Cancer Res 2002 (Glioblastoma) : Expression of a kinase dead dominant negative Akt mutant in the U87MG.DeltaEGFR cells similarly resulted in up-regulation of p27 and down-regulation of tumorigenicity in vivo
Rocha et al., Microsc Res Tech 2003 : Second, ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of Akt/PKB dephosphorylation/deactivation, c-Myc protein degradation, and p27 ( Kip1 ) protein induction ... Second, ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of Akt/PKB dephosphorylation/deactivation, c-Myc protein degradation, and p27 ( Kip1 ) protein induction
Sa et al., Exp Cell Res 2004 : For example, inhibitors of MEK and phosphatidylinositol-3-kinase induced p27 expression primarily in G1 phase, while inhibitors of AKT activity stimulated these levels primarily in S phase
Shin et al., J Biol Chem 2005 : In cells arrested in G ( 1 ) and then synchronized to enter into S phase, Akt mediated phosphorylation of Thr-157 p27 occurred in the cytosol during G ( 1 ) phase of the cell cycle
Wu et al., Am J Respir Cell Mol Biol 2006 : CTGF induced HLF proliferation ; enhanced the expression of cyclin D1 ; phosphorylated extracellular signal regulated kinase ( ERK ) 1/2, phosphoinositide 3-kinase (PI3-K), protein kinase B (PKB) , and DNA binding activity of signal transducers and activators of transcription-3 ( STAT3 ) ; and inhibited expression of p27 ( kip1 )
van Duijn et al., Prostate 2006 (Prostatic Neoplasms) : PI3K/Akt signaling regulates p27 ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells ... As shown in LNCaP cells, p27 ( kip1 ) expression inversely correlated with Skp2 expression, but Skp2 was not regulated by Akt ... In PC3 and DU145 cells, Skp2 is the main determinant in the PI3K/Akt dependent regulation of p27 ( kip1 )
Wu et al., Cancer Res 2006 (Breast Neoplasms...) : Expression of p27deltaNLS in MCF7 breast cancer cells down-regulated RhoA and increased motility, survival, and Akt levels without an effect on cell cycle distribution
Romano et al., J Endocrinol 2006 : Insulin had a replicating effect on PC Cl3 cells, induced the phosphorylation of PKB , decreased p27 ( kip ) expression and had no effect on the PKC-zeta cytosol-to-membrane translocation
Charette et al., Oncogene 2007 : Using DNA damage as a p27 nuclear import signal, we found that the E7 oncoprotein from human papillomavirus type 16 ( HPV-16 ), the etiological agent of cervical cancer, enhanced both the cytoplasmic retention of p27 and the migration of human foreskin keratinocytes ( HFKs ) in a phosphoinositide-3 kinase (PI3K)/Akt dependent manner using a standard wound assay
Yuan et al., Cancer Res 2007 (Breast Neoplasms...) : In sum, loss of p27 activated AIB1, E2F1, Gab2, and Akt ; increased cell migration and invasion ; caused antiestrogen insensitivity ; and promoted metastasis of breast cancer cells
Larrea et al., Mol Cell Biol 2008 : PI3K/PKB inhibition rapidly reduced p27pT157 and p27pT198 and dissociated cellular p27-cyclin D1-Cdk4 ... Thus, while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro, cyclin D1-Cdk4-p27 activation requires the tyrosine phosphorylation of p27
Lee et al., Oncogene 2009 (Breast Neoplasms) : Id-1 activates Akt mediated Wnt signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition
Festuccia et al., Endocr Relat Cancer 2009 (Disease Models, Animal...) : In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1, and p27/KIP1 , and inhibiting the activation of Akt activity and the expression of cyclin D1, Bcl-2, and Bcl-XL
Lee et al., Cell Mol Life Sci 2009 : Galectin-1 induced increase in cyclin expression and decrease in p27 ( kip1 ) was blocked by Akt inhibitor and rapamycin
Lee et al., Mol Cells 2009 : Lf ( Fe ( 3+ ) ) immediately induced Akt phosphorylation at Ser473, which subsequently induced the phosphorylation of two G1-checkpoint Cdk inhibitors, p21 ( Cip/WAF1 ) and p27 ( kip1 )
Villavicencio et al., Gynecol Oncol 2009 (Endometrial Hyperplasia...) : The PCOS condition is associated with increased Ser473-AKT phosphorylation, elevated expression of Ras, increased cytoplasmic abundance of p27 , and increased nuclear abundance of CDK2 in the endometrial epithelial cells
Chu et al., Leukemia 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These studies show the importance of BCR-ABL-Y177-AKT mediated p27 phosphorylation in altered p27 localization and enhanced proliferation and expansion of primary CML progenitors
Vaid et al., Carcinogenesis 2010 (Cell Transformation, Neoplastic...) : Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1, D2 and E and associated cyclin dependent kinases (CDKs)2, CDK4 and CDK6, ( ii ) upregulated Cip/p21 and Kip/p27 and ( iii ) inhibited the levels of phosphatidylinositol 3-kinase and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors
Kim et al., J Toxicol Environ Health 2010 (Prostatic Neoplasms) : Overexpression of constitutively active Akt attenuated ceramide induced Skp2 downregulation and p27 ( kip1 ) upregulation
Gopinath et al., Mol Oncol 2011 (Glioma) : uPAR and cathepsin B downregulation was recently shown to induce p27 expression through PI3K/Akt/FOXO3a signaling
Wang et al., PloS one 2012 : However, these AKT sites are not conserved in mouse, and it has not been clear whether AKT negatively regulates murine p27 ... These findings establish in vivo that murine p27 is not negatively regulated by AKT and indicate that proliferation in PI3 kinase/AKT pathway driven mouse models is mediated by p27 independent mechanisms that may be distinct from those in human
Chou et al., Br J Pharmacol 2013 : Overexpression of AKT1 , but not of AKT2, induced p21/p27 phosphorylation and increased cytosolic p21/p27 levels, as did homocysteine treatment