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IDO1 — NOS1
Text-mined interactions from Literome
Däubener et al., Adv Exp Med Biol 1999
:
We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced
IDO activity in uroepithelial cells is
due to stimulation of inducible
nitric oxide synthase
Franchi et al., Nitric Oxide 2001
:
This study was conducted to investigate the in vitro and in vivo
effects of lysine clonixinate ( LC ) and
indomethacin (INDO) on
NOS activity in rat lung preparation
Jackman et al., Naunyn Schmiedebergs Arch Pharmacol 2011
(Disease Models, Animal...) :
Mice were pre treated with vehicle, the
Ido1 inhibitor, 1-methyl-D-tryptophan ( 1-MT ; 50 mg/kg i.p. ) or the inducible
nitric oxide synthase ( Nos2 )
inhibitor , aminoguanidine ( AG, 100 mg/kg i.p. )
Darcy et al., PloS one 2011
(Sepsis) :
Increased
IDO activity ( measured by the kynurenine to tryptophan [ KT ] ratio in plasma )
causes T-cell apoptosis, vasodilation and
nitric oxide synthase inhibition
Alberati-Giani et al., J Immunol 1997
:
In MT2 macrophages, the induction of
IDO activity by IFN-gamma was further
increased by the presence of
NOS inhibitors, whereas culturing of IFN-gamma activated MT2 cells with NO generators produced a marked reduction of IDO activity expression