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ICOS — IL5
Text-mined interactions from Literome
Coyle et al., Immunity 2000
:
We suggest that
ICOS , the third member of the CD28/CTLA-4 family,
plays an important role in production of IL-2, IL-4,
IL-5 , and IFNgamma from recently activated T cells and contributes to T cell dependent B help in vivo
Wahl et al., J Am Soc Nephrol 2002
:
Interestingly,
interleukin-2 production by T cell hybridomas after antigen presentation by TEC was
enhanced by blocking antibodies to B7RP-1 and
ICOS
Bellinghausen et al., Immunology 2004
(Hypersensitivity) :
In this system, costimulation of
ICOS strongly
enhanced the production of the T helper 2 cytokines interleukin (IL)-4,
IL-5 and IL-10 and, to a lesser extent, secretion of the T helper 1 cytokine, interferon-gamma