Gene interactions and pathways from curated databases and text-mining

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ICOS — IL5

Text-mined interactions from Literome

Coyle et al., Immunity 2000 : We suggest that ICOS , the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5 , and IFNgamma from recently activated T cells and contributes to T cell dependent B help in vivo
Wahl et al., J Am Soc Nephrol 2002 : Interestingly, interleukin-2 production by T cell hybridomas after antigen presentation by TEC was enhanced by blocking antibodies to B7RP-1 and ICOS
Bellinghausen et al., Immunology 2004 (Hypersensitivity) : In this system, costimulation of ICOS strongly enhanced the production of the T helper 2 cytokines interleukin (IL)-4, IL-5 and IL-10 and, to a lesser extent, secretion of the T helper 1 cytokine, interferon-gamma