Gene interactions and pathways from curated databases and text-mining

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CASP5 — HTRA2

Text-mined interactions from Literome

Yamaguchi et al., Cancer Res 2003 (Colonic Neoplasms) : Treating HCT116 cells with THG results in caspase-8 activation ; Bid cleavage ; Bax conformational change and mitochondrial translocation ; the release of cytochrome c, Smac/Diablo, and Omi/HtrA2 into the cytosol ; caspase-3 activation ; and apoptosis
Srinivasula et al., J Biol Chem 2003 : In contrast, ectopic expression of mature wildtype Omi/HtrA2 , but not an active site mutant, induces potent caspase activation and apoptosis
Tillman et al., Cancer Res 2003 (Colonic Neoplasms) : In RKO, rottlerin induced the release of cytochrome c, HtrA2/Omi , Smac/DIABLO, and AIF from the mitochondria, potentiated in combination with TRAIL, with concomitant caspase activation and down-regulation of XIAP ... In RKO, rottlerin induced the release of cytochrome c, HtrA2/Omi , Smac/DIABLO, and AIF from the mitochondria, potentiated in combination with TRAIL, with concomitant caspase activation and down-regulation of XIAP
Suzuki et al., Cell Death Differ 2004 : Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways ... Omi/HtrA2 is a mitochondrial serine protease that is released into the cytosol during apoptosis and promotes cytochrome c ( Cyt c ) dependent caspase activation by neutralizing inhibitor of apoptosis proteins ( IAPs ) via its IAP binding motif ... Extramitochondrial expression of Omi/HtrA2 indirectly induced permeabilization of the outer mitochondrial membrane and subsequent Cyt c-dependent caspase activation in HeLa cells
Wu et al., Clin Exp Pharmacol Physiol 2004 : 3. The apoptotic effect induced by cinnamaldehyde could be further supported by the release of cytochrome c, Smac/Diablo and Omi/HtrA2 from mitochondria to the cytosol and activation of caspase 3
Liu et al., Circulation 2005 (Myocardial Infarction...) : Taken together, these results demonstrate for the first time that ischemia/reperfusion results in Omi/HtrA2 translocation from the mitochondria to the cytosol, where it promotes cardiomyocyte apoptosis via a protease activity dependent, caspase mediated pathway
Zhang et al., Sci China C Life Sci 2008 : The release of Cyt c, HtrA2 and Smac from mitochondria did not occur via the same mechanism, the release of Cyt c and HtrA2 was caspase independent and the release of Smac was caspase dependent ... The release of Cyt c, HtrA2 and Smac from mitochondria did not occur via the same mechanism, the release of Cyt c and HtrA2 was caspase independent and the release of Smac was caspase dependent
Winkler et al., Thromb Haemost 2013 : Inhibition of Omi/HtrA2 led to decreased levels of activated caspase-3/7 and caspase-9, but did not abolish loss of ??m or prevent release of Omi/HtrA2 from mitochondria