Gene interactions and pathways from curated databases and text-mining

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HSPD1 — MAPK14

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sasu et al., Circ Res 2001 (Chlamydophila Infections) : Together these results indicate that C pneumoniae and chlamydial hsp60 are potent inducers of human VSMC proliferation and that these effects are mediated , at least in part, by rapid TLR4 mediated activation of p44/p42 MAPK
Kim et al., Bone 2009 (Bone Resorption) : Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK