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AKT1 — HSPB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gabai et al., J Appl Physiol 2002
:
Some of these pathways enhance the ability of cells to survive heat shock, e.g., induction of molecular chaperones [ heat shock protein ( HSP ) HSP72 and HSP27 ],
activation of the protein kinases extracellular signal regulated kinase and
Akt , and phosphorylation of
HSP27
Rane et al., J Biol Chem 2003
:
To better understand the regulation of this signaling module, the hypothesis that Akt phosphorylation of
Hsp27 regulates its interaction with
Akt was tested ... Additionally, the interaction between
Hsp27 and Akt was
necessary for activation of
Akt in intact neutrophils
Nakagomi et al., J Neurosci 2003
:
Hsp27 expression significantly
inhibits JNK induced apoptosis as well as
Akt activation in PC12 cells and superior cervical ganglion neurons
Nakajima et al., Life Sci 2005
:
In the present study, we investigated whether
Akt is
involved in the phosphorylation of
HSP27 and the role of adenylyl cyclase-cAMP system ... SB203580, a p38 MAP kinase inhibitor, significantly suppressed the thrombin induced phosphorylation of Akt and the
Akt inhibitor
suppressed the phosphorylation of
HSP27
Suga et al., Arch Biochem Biophys 2005
(MAP Kinase Signaling System) :
In the present study, we investigated whether phosphatidylinositol 3-kinase
(PI3K)/protein kinase B ( Akt ) is
involved in the phosphorylation of
HSP27 in these cells ... These results suggest that
PI3K/Akt plays a part in the AVP induced phosphorylation of
HSP27 , maybe independently of p38 MAP kinase, in aortic smooth muscle A10 cells
Minelli et al., Peptides 2006
:
It greatly
enhances the phosphorylation of
hsp27 , alpha-B-crystallin, Cdc2, and p-38 MAPK, whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a,
PKB/Akt , PKCdelta, PKCgamma, and Erk2 ... It greatly
enhances the phosphorylation of
hsp27 , alpha-B-crystallin, Cdc2, and p-38 MAPK, whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a,
PKB/Akt , PKCdelta, PKCgamma, and Erk2
Takai et al., J Cell Biochem 2006
:
In the present study, we investigated whether phosphatidylinositol 3-kinase
(PI3K)/protein kinase B ( Akt ) is
involved in the induction of
HSP27 in these cells ...
Akt inhibitor, 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate,
reduced the
HSP27 induction stimulated by sphingosine 1-phosphate ... These results suggest that
PI3K/Akt plays a part in the sphingosine 1-phosphate stimulated induction of
HSP27 , maybe independently of p38 MAP kinase, in osteoblasts
O'Shaughnessy et al., J Biol Chem 2007
:
AKT dependent
HspB1 ( Hsp27 ) activity in epidermal differentiation
Wu et al., J Biol Chem 2007
:
Hsp27 regulates
Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex ... However, the
role of
Hsp27 in regulating
Akt activation was not examined ... This study tested the hypothesis that
Hsp27 regulates
Akt activation and promotes cell survival by scaffolding MK2 to the Akt signal complex ... Here we show that loss of
Akt/Hsp27 interaction by anti-Hsp27 antibody treatment
resulted in loss of
Akt/MK2 interaction, loss of Akt-Ser-473 phosphorylation, and induced PMN apoptosis ... Transfection of myristoylated
Akt ( AktCA ) in HK-11 cells
induced Akt-Ser-473 phosphorylation, activation, and
Hsp27-Ser-82 phosphorylation ... Silencing
Hsp27 expression inhibited Akt/MK2 interaction,
inhibited Akt phosphorylation and
Akt activation, and induced HK-11 cell death ... These studies collectively define a novel
role of
Hsp27 in regulating
Akt activation and cellular apoptosis by mediating interaction between Akt and its upstream activator MK2
Liu et al., Chin Med J (Engl) 2007
:
Hsp27 inhibits oxidative stress induced H9c2 damage and inhibition of ROS generation and the augmentation of
Akt activation may be
involved in the protective signaling
Havasi et al., J Biol Chem 2008
:
During stress,
Hsp27 expression prevented the inactivation of Akt, a pro-survival kinase, and
increased the interaction between
Akt and Bax, an Akt substrate ... Furthermore, distinct PI3-kinase inhibitors completely abrogated the protective
effect of
Hsp27 expression on
Akt activation, Bax inactivation, and cell survival
Zoubeidi et al., Cancer Res 2010
(MAP Kinase Signaling System...) :
Hsp27 overexpression
increases IGF-I induced phosphorylation of Erk, p90Rsk, and
Akt
Shao et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
HSP27 , a
regulator of
Akt , also exhibited increased phosphorylation ( Ser82 ) during ischemia with TH
Kanagasabai et al., Mol Cancer Res 2010
(Adenocarcinoma) :
Our results showed that
Hsp27 expression and its direct chaperoning interaction
increases Akt stability, and p21 phosphorylation and nuclear-to-cytoplasm translocation, both essential effects for the survival of UV-induced DNA damaged cells
Hayashi et al., Cell Death Differ 2012
:
Furthermore, we show that
Hsp27 regulation of PEA-15 activity occurs in an
Akt dependent manner
Konishi et al., FEBS Lett 1997
:
When the cells were treated with H2O2,
PKB was activated gradually and the association of
Hsp27 with PKB
increased concurrently with the enhancement of PKB activity