Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MAP3K5
→
Complex of HSPA1A-MAP3K5
(decreases, HSPA1A/MAP3K5 Activity)
Park et al., Mol Cell Biol 2002* Evidence: Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). Overexpression of Hsp72 also inhibited H(2)O(2)-induced activation of ASK1 as well as that of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. Recombinant Hsp72 bound directly to ASK1 and inhibited ASK1 activity in vitro
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *