Gene interactions and pathways from curated databases and text-mining

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HSPA1A — MAP3K5

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAP3K5 → Complex of HSPA1A-MAP3K5 (decreases, HSPA1A/MAP3K5 Activity) Park et al., Mol Cell Biol 2002*
    Evidence: Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). Overexpression of Hsp72 also inhibited H(2)O(2)-induced activation of ASK1 as well as that of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. Recombinant Hsp72 bound directly to ASK1 and inhibited ASK1 activity in vitro

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *