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HSP90B1 — IGF2

Text-mined interactions from Literome

Ostrovsky et al., Mol Biol Cell 2009 : GRP94 interacts physically and transiently with pro-IGF-II intermediates, and its activity is essential for secretion of active IGF-II , thus establishing IGF-II as a client of GRP94
Ostrovsky et al., Proc Natl Acad Sci U S A 2009 : To decipher the mode of GRP94 action in vivo, we exploited our finding that GRP94 is necessary for the production of insulin-like growth factor (IGF)-II and developed a cell based functional assay
Ostrovsky et al., Biochim Biophys Acta 2010 : Thus, the major effect of GRP94 on muscle differentiation is mediated by its regulation of IGF production