Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — PRKDC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kang et al., FEBS J 2008 : Additionally, loss of DNA-PKcs led to attenuated expression of Hsp70/Hsp90 , accelerated hypoxia-inducible factor-1alpha degradation, and increased susceptibility to hypoxia induced cell death
Solier et al., Proc Natl Acad Sci U S A 2012 : We also show that DNA-PK is a client of HSP90a and that HSP90a is required for full DNA-PK activation, ?-H2AX formation, DNA fragmentation, and apoptotic body formation ... In contrast, HSP90 inhibition by geldanamycin markedly enhances TRAIL induced DNA-PK and H2AX activation