◀ Back to PRKDC
HSP90AA1 — PRKDC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kang et al., FEBS J 2008
:
Additionally, loss of
DNA-PKcs led to attenuated expression of
Hsp70/Hsp90 , accelerated hypoxia-inducible factor-1alpha degradation, and increased susceptibility to hypoxia induced cell death
Solier et al., Proc Natl Acad Sci U S A 2012
:
We also show that DNA-PK is a client of HSP90a and that
HSP90a is
required for full
DNA-PK activation, ?-H2AX formation, DNA fragmentation, and apoptotic body formation ... In contrast,
HSP90 inhibition by geldanamycin markedly
enhances TRAIL induced
DNA-PK and H2AX activation