◀ Back to HIF1A
HIF1A — HSP90AA1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A (HIF1A)
→
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A (HIF1A)
→
Hsp90 (HSP90AA1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
→
Hsp90 (HSP90AA1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
→
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/Hsp90 complex (HIF1A-HSP90AA1)
→
RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
Hsp90 (HSP90AA1)
→
HIF1A/RACK1/Elongin B/Elongin C complex (GNB2L1-TCEB2-TCEB1-HIF1A)
(modification, collaborate)
Isaacs et al., J Biol Chem 2002, Liu et al., Mol Cell 2007, Gradin et al., Mol Cell Biol 1996
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
HIF1A
—
HSP90AA1
Hogenesch et al., J Biol Chem 1997*
-
IRef Bind_translation Interaction:
HIF1A
—
HSP90AA1
(unspecified method)
Hogenesch et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Kong et al., Mol Cell Biol 2006*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Qian et al., Cancer Res 2006*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Fu et al., Mol Cancer Ther 2007*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Choi et al., J Biol Chem 2010*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Liu et al., Mol Cell 2007
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(direct interaction, pull down)
Liu et al., Mol Cell 2007
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Lee et al., Int J Cancer 2012*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Katschinski et al., Cell Physiol Biochem 2004*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(direct interaction, pull down)
Katschinski et al., Cell Physiol Biochem 2004*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Trisciuoglio et al., PloS one 2010*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Zhou et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(direct interaction, pull down)
Ueda et al., FEBS Lett 2008*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(direct interaction, pull down)
Hogenesch et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
HIF1A
—
HSP90AA1
(physical association, affinity chromatography technology)
Kubo et al., Biochem Biophys Res Commun 2004*
-
IRef Hprd Interaction:
HIF1A
—
HSP90AA1
(in vitro)
Hogenesch et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
HIF1A
—
HSP90AA1
(in vivo)
Hogenesch et al., J Biol Chem 1997*
-
IRef Intact Interaction:
HIF1A
—
HSP90AA1
(direct interaction, surface plasmon resonance)
Ueda et al., FEBS Lett 2008*
-
IRef Mppi Interaction:
HIF1A
—
HSP90AA1
(coimmunoprecipitation)
Hogenesch et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
HIF1A
—
HSP90AA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Katschinski et al., J Biol Chem 2002
:
Inhibition of the ATP dependent chaperone activity of
HSP90 by novobiocin or geldanamycin
prevented heat induced as well as hypoxia induced
HIF-1alpha accumulation, indicating a common role of the HSP90 chaperone activity in HIF-1alpha stabilization by these two environmental parameters
Katschinski et al., Cell Physiol Biochem 2004
:
Hypoxic accumulation of HIF-1alpha was delayed in a novel cell model deficient for HSP90beta as well as after treatment of wild-type cells with the HSP90 inhibitor geldanamycin, suggesting that
HSP90 activity is
involved in the rapid
HIF-1alpha protein induction
Kubis et al., Biochim Biophys Acta 2005
(Anoxia) :
We conclude that in skeletal muscle cells,
HIF1alpha , in contrast to other tissues, may, in addition to its regulation by degradation, also be
regulated by binding to
HSP90 and subsequent inhibition of its import into the nuclei
Ono et al., J Cell Biochem 2006
:
The inhibition of proteasome in the growth phase led to HIF-1alpha protein accumulation, whereas in the differentiation phase the inhibition of
Hsp90 , which stabilizes HIF-1alpha,
suppressed HIF-1alpha accumulation
Liu et al., Mol Cell 2007
:
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O ( 2 ) -independent and
HSP90 inhibitor
induced degradation of
HIF-1alpha ... Inhibition of
heat-shock protein 90 (HSP90) leads to O ( 2 ) /PHD/VHL independent degradation of
HIF-1alpha
Liu et al., Cell cycle (Georgetown, Tex.) 2007
:
Inhibitors of
heat shock protein 90 (HSP90) dissociate HSP90 from HIF-1alpha and
induce O2/PHD/VHL independent degradation of
HIF-1alpha
Kim et al., Cancer Res 2009
(Carcinoma, Non-Small-Cell Lung...) :
Inhibition of
Hsp90 function by 17-allylamino-17-demethoxygeldanamycin or deguelin, a novel natural inhibitor of Hsp90,
suppressed increases in
HIF-1alpha/Hsp90 interaction and HIF-1alpha expression in radioresistant cells
van de Sluis et al., PloS one 2009
:
Inhibition of
HSP90 activity with 17-Allylamino-17-demethoxygeldanamycin ( 17-AAG )
increased COMMD1 mediated
HIF-1alpha degradation independent of ubiquitin and pVHL
Zhang et al., Cancer Res 2010
:
Further, decreased levels of endogenous Hsp90/Hsp70 proteins in JNK1-/- cells affected the protective roles of these chaperones in stabilizing newly synthesized HIF-1alpha, whereas enforced expression of
Hsp90/Hsp70 in JNK1-/- cells
increased HIF-1alpha stability relative to parental control cells