Gene interactions and pathways from curated databases and text-mining

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CASP5 — HRK

Text-mined interactions from Literome

Putcha et al., Neuron 2003 : Trophic factor deprivation ( TFD ) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1 dependent transactivation of the BH3-only BCL-2 proteins BIM ( EL ) and HRK , which in turn are critical for BAX dependent cytochrome c release, caspase activation , and apoptosis
Pyrzynska et al., Mol Oncol 2013 (Glioma) : Consistently, APPL2 overexpression reduces expression of HRK and caspase activation in cells treated with apoptosis inducers, resulting in the enhancement of cell viability