Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

HRH1 — MAPK14

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK14 → HRH1 (increases, HRH1 Activity, MAPK14 Activity)
    Evidence: Histamine induced a time-dependent, H1 receptor-mediated activation of p38 MAP kinase (p38), p44/42 MAP kinase (ERK), and c-jun terminal NH2 kinase (JNK).

Text-mined interactions from Literome

Pype et al., Am J Respir Crit Care Med 2001 (Bronchial Hyperreactivity) : An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38 MAPK inhibitor, blocked the IL-1beta induced H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta ... Here, we have demonstrated that IL-1beta desensitizes H(1)R , which involves the activation of p38 MAPK and NF-kappaB, leading to the expression of cox-2 and the synthesis of PGE ( 2 )
Noubade et al., J Clin Invest 2007 (Encephalomyelitis, Autoimmune, Experimental...) : Moreover, H1R signaling at the time of TCR ligation was required for activation of p38 MAPK , a known regulator of IFN-gamma expression