Gene interactions and pathways from curated databases and text-mining

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AKT1 — HPSE

Text-mined interactions from Literome

Gingis-Velitski et al., J Biol Chem 2004 : Heparanase mediated Akt phosphorylation was independent of its enzymatic activity or the presence of cell membrane HS proteoglycans and was augmented by heparin
Ilan et al., Int J Biochem Cell Biol 2006 (Disease Progression...) : Heparanase enhances Akt signaling and stimulates PI3K- and p38 dependent endothelial cell migration and invasion
Ben-Zaken et al., Biochem Biophys Res Commun 2007 : Heparanase induces Akt phosphorylation via a lipid raft receptor
Zhang et al., Zhonghua Bing Li Xue Za Zhi 2008 (Adenocarcinoma...) : Western-blot showed that inhibition of heparanase expression led to reduced Akt phosphorylation
Riaz et al., J Biol Chem 2013 : Characterization of Heparanase induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence ... Protein suppression using specific siRNAs revealed that heparanase induced phosphorylation of AKT at Ser-473 was RICTOR-mTOR dependent, whereas ILK and PAK1/2 were dispensable ... Heparanase induced AKT phosphorylation was low in mouse embryonic fibroblast cells expressing a RAS interaction-defective p110a compared with wild type cells, indicating that RAS has an important role in the PI3K-AKT activation ... Adhesion via either aVß3 or a5ß1 promoted heparanase induced AKT phosphorylation, and a stronger effect was seen when both integrins were engaged ... Simultaneous inhibition of FAK and PYK2 using a chemical inhibitor, or suppression of their expression, inhibited heparanase induced AKT activation and cell proliferation