Gene interactions and pathways from curated databases and text-mining

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HMOX1 — NOS1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: NOS1 → HMOX1 (decreases, HMOX1 Activity, NOS1 Activity)
    Evidence: where CO takes over the roles of NO under conditions of oxidative stress (Maines, 1997). Therefore, HO activity is important in controlling the activity of heme proteins, such as cytochromes P450, COX, guanylyl cyclase, and NOS, not only at the level of the intracellular heme pool available for the apo-heme proteins (Kappas and Drummond, 1986) but possibly also at the level of HO's downstream effector molecule CO by interactions with the heme group (Haider et al., 2002).

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Datta et al., J Am Soc Nephrol 1999 (Glomerulonephritis...) : Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
Vicente et al., Br J Pharmacol 2001 : NOS inhibition by L-N ( G ) -nitroarginine methyl ester ( L-NAME ) or 1400 W abolished nitrite production and strongly reduced HO-1 expression
Coito et al., Transplantation 2002 (Obesity...) : Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury ... HO-1 gene transfer significantly prolongs survival of steatotic orthotopic liver transplants, depresses macrophage infiltration, suppresses local expression of inducible nitric oxide synthase , and modulates pro- and antiapoptotic pathways
Vicente et al., Biochem Pharmacol 2003 : Inhibition of NO production and/or NOS expression by incubating macrophages with different drugs inhibiting NOS activity or modulating the redox state of the cell, such as N-acetylcysteine (NAC) resulted in inhibition of HO-1 expression, suggesting that NO is an endogenous mediator of this stress response
Vicente et al., J Pharmacol Exp Ther 2003 (Inflammation) : Up-regulation of HO-1 by hemin administration resulted in inhibition of nitric-oxide synthase-2 activity, cellular infiltration into the air pouch exudate, and plasmatic exudation
Yang et al., J Biomed Sci 2004 : Heme oxygenase-1 attenuates interleukin-1beta induced nitric oxide synthase expression in vascular smooth muscle cells
Maeshima et al., Biochem Pharmacol 2005 (Respiratory Distress Syndrome, Adult...) : HA pretreatment markedly induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity
Datta et al., Nephrol Dial Transplant 2006 (Disease Models, Animal...) : Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis
Ashino et al., Mol Immunol 2008 : Negative feedback regulation of lipopolysaccharide induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
Kim et al., Biomed Pharmacother 2008 : Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages
Manalo et al., Biochem J 2008 : OG, unlike HS, induced a sharp increase in HO-1 ( haem oxygenase-1 ) transcription at 4 h, which declined rapidly within 24 h, whereas modest increases in iNOS [ inducible ( nitric oxide synthase ) ] and constitutive NOS [ eNOS ( endothelial NOS ) ] were detected over the control
Choi et al., Gastroenterology 2008 (Diabetes Mellitus, Experimental...) : Induction of HO-1 by hemin decreased reactive oxygen species, rapidly restored Kit and neuronal nitric oxide synthase expression, and completely normalized gastric emptying in all mice
Kim et al., J Periodontol 2009 : The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells
Pi et al., J Periodontal Res 2010 : Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
Santa-Cruz et al., Phytochemistry 2010 : This study shows that nitric oxide ( NO ) protects against oxidative damage and that nitric oxide synthase (NOS)-like activity is also required for HO-1 induction under UV-B radiation
Kachadourian et al., Free Radic Biol Med 2011 : They have been reported to inhibit the synthesis of the inducible nitric oxide synthase and to induce the expression of heme oxygenase-1
Kil et al., Journal of clinical biochemistry and nutrition 2012 : Heme oxygenase-1 expression via activation of nuclear factor-erythroid 2-related factor 2 inhibits nitric oxide production and inducible nitric oxide synthase expression in activated macrophages
Lyoumi et al., Crit Care Med 1998 (Acute Disease...) : a ) To evaluate in vivo, in rat liver, heme oxygenase-1 (HO-1) messenger RNA ( mRNA ) expression level and the regulation of 3',5'-cyclic guanosine monophosphate ( cGMP ) production during hepatic regeneration, localized inflammation, and systemic inflammation ; and b ) to investigate the effect of the induction of cytochrome P-450 and nitric oxide synthase (NOS) inhibition on HO-1 mRNA level and cGMP production in the liver