Gene interactions and pathways from curated databases and text-mining

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HMOX1 — MAPK14

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Brouard et al., J Exp Med 2000 : Expression of HO-1 or exposure of ECs to exogenous CO enhanced p38 MAPK activation by TNF-alpha
Ryter et al., Antioxid Redox Signal 2002 (MAP Kinase Signaling System) : Surprisingly, SB203580, an inhibitor of p38 MAPK , and PD98059, an inhibitor of mitogen activated protein kinase kinase ( MEK1 ), strongly enhanced hypoxia induced HO-1 mRNA expression in PAEC
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : The induced levels of HO-1 and p21 were significantly reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Anwar et al., Free Radic Biol Med 2005 (Arteriosclerosis...) : Inhibitors of protein kinase C ( PKC ) or mitogen activated protein kinases ( MAPK ) p38 ( MAPK ) and MEK or c-jun-NH2-terminal kinase ( JNK ) significantly attenuated induction of HO-1
Huang et al., Ann N Y Acad Sci 2005 : The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-kappaB) inhibitors, but not by mitogen activated protein kinase ( MAPK ) inhibitors
Ogborne et al., Arterioscler Thromb Vasc Biol 2005 (Leukemia) : Alpha-lipoic acid induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen activated protein kinase in human monocytic cells
Zwerina et al., FASEB J 2005 (Arthritis, Rheumatoid...) : Up-regulation of HO-1 was mediated by activation of MAPK and primarily prevented differentiation of osteoclast precursors to osteoclasts, whereas it did not affect mature osteoclasts
McNally et al., Int J Mol Med 2007 : PKC and p38 MAPK activity are required for full induction of HO-1
Cooper et al., Toxicol Appl Pharmacol 2007 : These findings suggest that the ERK/MAPK activation is necessary but not sufficient for optimal arsenite stimulated HO-1 induction
Kocanova et al., Apoptosis 2007 (MAP Kinase Signaling System...) : p38 ( MAPK ) inhibitors or small interfering RNA ( siRNA ) for p38 ( MAPK ) suppress HO-1 induction after PDT and complete repression is attained when p38 and PI3K antagonists are combined
Kim et al., Lung Cancer 2008 (Lung Neoplasms) : In addition, pharmacologic inhibitors of MAPK suppressed the induction of HO-1 and Nrf2 expression by cisplatin
Hsu et al., Am J Physiol Regul Integr Comp Physiol 2008 (Hemorrhage...) : Mechanism of estrogen mediated intestinal protection following trauma-hemorrhage : p38 MAPK dependent upregulation of HO-1 ... p38 MAPK activation also results in the induction of heme oxygenase (HO)-1 , which exerts potent anti-inflammatory effects ... This was accompanied with a decrease in intestinal p38 MAPK activity and increase in HO-1 expression
Yang et al., Free Radic Biol Med 2008 (Lymphoma) : Gallium nitrate increased the phosphorylation of p38 mitogen activated protein kinase and activated Nrf-2, a regulator of HO-1 gene transcription
Park et al., Oncol Rep 2008 (Lung Neoplasms) : MAPK inhibitors blocked the induction of HO-1 by combination treatment
Naidu et al., J Immunol 2008 : The antioxidant N-acetylcysteine and inhibitors of p38 MAPK or serine/threonine kinase CK2 blocked PMA dependent HO-1 gene activation
Guan et al., J Cell Biochem 2008 (MAP Kinase Signaling System) : We examined the role of Mitogen Activated Protein Kinase ( MAPK ) pathways in HO-1 regulation by EA. Primary rat aortic smooth muscle cells were exposed to EA or physiologic pH
Han et al., J Pharmacol Exp Ther 2009 : Either phosphatidylinositol 3-kinase or mitogen activated protein kinase cascade inhibitors blocked the HO-1 induction
Rémy et al., J Immunol 2009 : HO-1 and CO inhibited LPS induced activation of the IFN regulatory factor 3 pathway and their effects were independent of p38, ERK, and JNK MAPK
Huang et al., Toxicol Appl Pharmacol 2009 : Inhibition of the p38 mitogen activated protein kinase pathway significantly blocked HO-1 induction by METH and aggravated METH neurotoxicity
Park et al., Biochimie 2010 (Colonic Neoplasms) : The pharmacological inhibition of ERK and p38 MAPK inhibited rottlerin induced HO-1 up-regulation
Genc et al., Cell Biochem Funct 2010 : These results suggest that Epo induces neural HO-1 expression through the activation of PI3K, MAPK , and Nrf2 pathways, and this may unveil a novel mechanism which mediates the cytoprotective responses elicited by Epo
Ohnishi et al., Brain Res 2010 (Brain Injuries...) : Overall, these results suggest that p38 MAPK dependent induction of HO-1 supports survival of striatal microglia during thrombin insults
Chen et al., Food Chem Toxicol 2010 : Western blot showed that hesperidin facilitated ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby inducing cytoprotective heme oxygenase-1 (HO-1) expression
Seidel et al., Respir Res 2010 (Airway Remodeling) : HO-1 expression was reversed by GSH-OEt, or p38 MAPK inhibition , or HO-1 siRNA, which all reversed the anti-proliferative effect of DMF
Carchman et al., Hepatology 2011 (Liver Diseases) : Sepsis or LPS induced autophagy protects against hepatocellular death, in part via an HO-1 p38 MAPK dependent signaling
Lee et al., J Cell Biochem 2011 (MAP Kinase Signaling System) : Small interfering RNA and pharmacological inhibitors of PKC-d and p38 MAPK attenuated HO-1 induction in fisetin stimulated HUVECs
Liang et al., Mol Cell Biochem 2011 : The pharmacological inhibition of cJun-N-terminal kinases ( JNKs ) blocked the DMSO induced HO-1 up-regulation, while inhibition of extracellular regulated kinase and p38-MAPK did not block heme oxygenase-1 up-regulation
Seidel et al., Eur Respir J 2013 : DMF inhibited CXCL10 secretion and increased HO-1 levels, and p38 mitogen activated protein kinase ( MAPK ) inhibition reduced DMF dependent HO-1 expression
Bang et al., J Ethnopharmacol 2012 (MAP Kinase Signaling System) : These results suggest that AJ suppresses LPS induced NO production and iNOS expression in macrophages through the inhibition of I?B/NF-?B and MAPK as well as the Nrf2 mediated HO-1 induction
Kästle et al., Free Radic Biol Med 2012 (MAP Kinase Signaling System) : Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition ... In this study we demonstrate that the up-regulation of HO-1 on proteasome inhibition is mediated by p38MAPK and Nrf-2
Tsai et al., Cellular oncology (Dordrecht) 2012 (Carcinoma, Non-Small-Cell Lung...) : In addition, we found that HO-1 expression can be inhibited by PI3K and AKT inhibitors, but not by MAPK inhibitors
Liu et al., PloS one 2012 (Shock, Hemorrhagic...) : These results suggest that the protective effect of tropisetron administration on alleviation of hepatic injury after trauma-hemorrhage is likely mediated through p38 MAPK dependent HO-1 expression
Wang et al., Apoptosis 2013 : Furthermore, momordin Ic combination with NAC influenced MAPK, PI3K/Akt and HO-1, iNOS pathways, MAPK and PI3K/Akt pathways also regulated the expression of HO-1 and iNOS
Deng et al., Cell Biol Toxicol 2013 : Evaluation of signaling pathways showed that a phosphatidylinositol 3-kinase (PI3K) inhibitor ( LY294002 ), but not an ERK 1/2 inhibitor ( PD98059 ) or a p38 MAPK ( SB203580 ), significantly down-regulated PM2.5 induced Nrf2 nuclear translocation and HO-1 mRNA expression, indicating PI3K/AKT is involved in the signaling pathway leads to the PM2.5 induced nuclear translocation of Nrf2 and subsequent Nrf2 mediated HO-1 transcription
Gu et al., International journal of medical sciences 2013 (MAP Kinase Signaling System...) : Additionally, the potential roles of ERK, p 38 MAPK and JNK in the regulation of propofol induced endogenous HO-1 expression in SH-SY5Y cells were estimated by Western blotting assays
Elbirt et al., J Biol Chem 1998 (Carcinoma, Hepatocellular...) : This construct was used to investigate the role of mitogen activated protein ( MAP ) kinases in arsenite mediated heme oxygenase-1 gene expression