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EPO — HMOX1

Text-mined interactions from Literome

Katavetin et al., Biochem Biophys Res Commun 2007 (Kidney Diseases) : Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress ... In this study we investigated whether pleiotropic effects of EPO may involve regulation of heme oxygenase (HO)-1 , an anti-oxidative stress protein ... We then evaluated whether EPO induces HO-1 and ameliorates renal injury in vivo ... In conclusion, EPO induced HO-1 expression is likely to provide cytoprotection against oxidative stress
Genc et al., Cell Biochem Funct 2010 : Here, we investigated whether Epo affects the transcription and activation of nuclear factor erythroid 2-related factor 2 ( Nrf2 ), which is a key transcription factor of the cellular anti-oxidant defense system, and mRNA expression of its target genes including heme oxygenase-1 (HO-1) ... In cultured human SH-SY5Y neuroblastoma cells, Western blotting, immunohistochemistry, and real-time PCR analysis demonstrated that Epo induced nuclear translocation of Nrf2 and upregulates HO-1 expression ... These results suggest that Epo induces neural HO-1 expression through the activation of PI3K, MAPK, and Nrf2 pathways, and this may unveil a novel mechanism which mediates the cytoprotective responses elicited by Epo
Chen et al., Clin Exp Immunol 2010 (Encephalomyelitis, Autoimmune, Experimental) : To assess the effect of EPO on endogenous HO-1 in EAE, we investigated expression of HO-1 mRNA by real-time polymerase chain reaction ( RT-PCR ), protein expression centrally and peripherally by Western blot and immunohistochemistry and mean fluorescence intensity of splenic HO-1 by flow cytometry ... Together, our data show that in EAE, EPO induction of endogenous HO-1 and modulation of adaptive immunity both centrally and peripherally may involve the repression of inflammatory responses