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AKT1 — HMOX1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HMOX1 → AKT1 (increases, HMOX1 Activity)
  Evidence: We next infected HUVECs with a dominant-negative form of Akt and found that it blocked the Nrf2 activation and HO-1 expression (Figure 7B).

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: AKT1 — HMOX1 (in vivo) Salinas et al., FEBS Lett 2004*
• IRef Hprd Interaction: AKT1 — HMOX1 (in vitro) Salinas et al., FEBS Lett 2004*

Text-mined interactions from Literome

Salinas et al., J Biol Chem 2003 : In this study, we demonstrate that nerve growth factor (NGF) prevents the accumulation of ROS in dopaminergic PC12 cells challenged with the Parkinson 's disease related neurotoxin 6-hydroxydopamine ( 6-OHDA ) by a mechanism that involves PI3K/Akt dependent induction of the stress response protein heme oxygenase-1 (HO-1)
Salinas et al., FEBS Lett 2004 (Second Messenger Systems) : Isotopic 32P labeling of HEK293T cells confirmed that HO-1 is a phosphoprotein and that the basal HO-1 phosphorylation is increased by Akt1 activation ... Although the changes in activity are small, this study provides the first evidence for a role of the survival kinase Akt in the regulation of HO-1
Kim et al., Ann N Y Acad Sci 2004 : Thus, the induction of HO-1 expression and the activation of Akt/PKB by 15d-PGJ ( 2 ) and PGA ( 2 ) are likely to confer cytoprotective or antiapoptotic effects exerted by these cyPGs ... Thus, the induction of HO-1 expression and the activation of Akt/PKB by 15d-PGJ ( 2 ) and PGA ( 2 ) are likely to confer cytoprotective or antiapoptotic effects exerted by these cyPGs
Wijayanti et al., J Biol Chem 2005 (Inflammation) : Accordingly, overexpressed constitutively active PKB markedly up-regulated HO-1 promoter activity ... Finally, AEBSF- and PKB dependent induction of HO-1 promoter activity was reduced by simultaneous mutation of an E-box motif ( -47/-42 ) and a cAMP response element/AP-1 element ( -664/-657 ) of the proximal HO-1 gene promoter
Pischke et al., Cell Mol Biol Incl Cyto Enzymol 2005 (Inflammation) : Since activation of heme oxygenase-1 and PI3K/Akt both protect the cellular environment, we postulated that PI3K/Akt can regulate the induction of heme oxygenase-1 by proinflammatory stress
Brunt et al., Arterioscler Thromb Vasc Biol 2006 : Inhibition of PI3K-Akt reduced induction of HO-1 protein expression by H2O2 and blocked its anti-apoptotic effects
Lin et al., Eur J Pharmacol 2007 : In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signaling pathway in TGF-beta1 induced HO-1 expression in human lung epithelial cells ( A549 )
Hsu et al., J Leukoc Biol 2007 (Hemorrhage...) : Mechanism of estrogen mediated attenuation of hepatic injury following trauma-hemorrhage : Akt dependent HO-1 up-regulation ... Akt activation also leads to the induction of heme oxygenase (HO)-1
Park et al., Neuropharmacology 2007 (Anoxia) : Akt dependent heme oxygenase-1 induction by NS-398 in C6 glial cells : a potential role for CO in prevention of oxidative damage from hypoxia ... NS-398 increased phosphorylation of Akt , and LY-294002, a specific PI(3) kinase inhibitor, inhibited NS-398 induced HO-1 expression
Pachori et al., J Mol Cell Cardiol 2007 (Anoxia...) : Furthermore, cardiac expression of HO-1 increased basal phosphorylated Akt levels and decreased infarct size in response to LAD ligation and release induced I/R injury ... Conversely, PI3K inhibition reversed the effects of HO-1 on Akt phosphorylation, cell death and infarct size ... In addition, knockdown of biliverdin reductase ( BVR ) expression with siRNA attenuated HO-1 induced Akt phosphorylation and increased H/R induced apoptosis of H9c2 cells
Min et al., Glia 2008 : Moreover, the nucleoside stimulated Akt phosphorylation, and suppressors of PI3K ( LY294002 and wortmannin ) reduced adenosine induced HO-1 expression
Zhang et al., Free radical research 2008 : Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2 ... In conclusion, this study proved that CHL exerts antioxidant effect by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2
Kim et al., Biochem Pharmacol 2008 : Taken together, these findings suggest that 15d-PGJ ( 2 ) augments cellular antioxidant defense capacity through activation of Akt and ERK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction , thereby protecting the PC12 cells from H2O2 induced oxidative cell death
Hsu et al., Crit Care Med 2009 (Shock, Hemorrhagic) : Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage : Akt dependent HO-1 up-regulation ... Because administration of 17beta-estradiol following trauma-hemorrhage improves cardiovascular responses, we investigated whether the salutary effects of 17beta-estradiol on cardiac function are mediated via Akt dependent heme oxygenase-1 up-regulation under those conditions ... These results suggest that the 17beta-estradiol meditated improvement in cardiac function following trauma-hemorrhage occurs via Akt dependent heme oxygenase-1 up-regulation
Sauvé et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : Increased cardiac expression of phosphorylated AKT ( pAKT ), pGSK3beta, and atrial natriuretic peptide (ANP) was detected in the nonischemic Dpp4 ( -/- ) heart, and HO-1 , ANP, and pGSK3beta proteins were induced in nonischemic hearts from diabetic mice treated with sitagliptin or metformin
Yu et al., Surgery 2010 (Hemorrhage) : Role of Akt dependent up-regulation of hemeoxygenase-1 in resveratrol mediated attenuation of hepatic injury after trauma hemorrhage ... Akt activation also leads to the induction of hemeoxygenase (HO)-1 , which exerts potent anti-inflammatory effects ... These findings collectively suggest that the salutary effects of resveratrol administration on attenuation of hepatic injury after trauma hemorrhage are likely mediated via up-regulation of Akt dependent HO-1 expression
Romero et al., J Pineal Res 2010 (Neuroblastoma) : The neuroprotective effect was prevented by chelerythrine, LY294002, and Sn ( IV ) protoporphyrin IX dichloride ( SnPP ), indicating the participation of the PKC/PI3K/Akt activation and induction of the antioxidant enzyme heme oxygenase-1
Hinkelmann et al., Eur J Pharm Sci 2010 : The increased HO-1 mRNA stability by this compound was blocked by inhibition of PI3K/Akt , but not by that of p38 MAPK
Lu et al., Biol Psychiatry 2010 (Inflammation) : In addition, DHA caused AKT and ERK activation in a time dependent manner, and the DHA induced HO-1 upregulation could be attenuated by PI-3 kinase/AKT and MEK/ERK inhibitors
Park et al., Int Immunopharmacol 2011 : Schisandra chinensis a-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide stimulated macrophages
Lee et al., Food Chem Toxicol 2012 (Mesothelioma) : Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane treated human mesothelioma MSTO-211H cells ... Overall, our results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane treated MSTO-211H cells
Chen et al., Int Immunopharmacol 2012 : Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2 related factor-2 signaling pathway in astrocytes
Hwang et al., International journal of molecular sciences 2012 : APV induced Akt phosphorylation as well as activation of heme oxygenase-1 (HO-1) , eNOS, and nuclear factor E2-related factor 2 ( Nrf2 ), which may protect vascular inflammation caused by HG
Hsu et al., Eur J Pharm Sci 2012 : BBR ( 0.1-10 nM ) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction , which were blocked by a PI3K inhibitor, LY294002
Dal-Cim et al., Neurochem Int 2012 (Neuroblastoma) : In conclusion, our results show that guanosine can afford protection against mitochondrial oxidative stress by a signaling pathway that implicates PI3K/Akt/GSK-3ß proteins and induction of the antioxidant enzyme HO-1
Tsai et al., Cellular oncology (Dordrecht) 2012 (Carcinoma, Non-Small-Cell Lung...) : In addition, we found that HO-1 expression can be inhibited by PI3K and AKT inhibitors, but not by MAPK inhibitors
Chen et al., J Huazhong Univ Sci Technolog Med Sci 2012 : 1,2,3,4,6-penta-O-galloyl-ß-D-glucose protects PC12 Cells from MPP ( + ) -mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt dependent manner ... Moreover, ß-PGG induced Nrf2 nuclear translocation, which was found to be upstream of ß-PGG induced HO-1 expression, and the activation of ERK and Akt , a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation, HO-1 expression and neuroprotection
Wu et al., Circ Res 2013 (Inflammation...) : Inhibition of phosphatidylinositol 3-kinase/Akt reduced the ( A-I ) rHDL mediated increase in HO-1 , but not DHCR24 expression
Hsu et al., J Surg Res 2013 (Lung Injury...) : Our results collectively suggest that Akt dependent HO-1 upregulation may play a critical role in E2-meditated lung protection after trauma-hemorrhage
Chien et al., Free Radic Biol Med 2013 (Genetic Predisposition to Disease...) : Akt and ERK are involved in HO-1 induction after oxidative stress
Yang et al., Oxidative medicine and cellular longevity 2013 : In conclusion, these results suggest that SPD induces PI3K/Akt-Nrf2 mediated HO-1 expression in human endothelial cells, which may have a role in cytoprotection of the cells against oxidative stress induced death