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HLA-DRB1 — IL12A

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
  Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Toyokawa et al., Anticancer Res 2002 : Both OK432 and KP-40 were found to up-regulate the activity of myeloid-lineage DCs : the expression of major histocompatibility complex ( MHC) class II molecules and adhesion/costimulatory molecules increased , and the production of IL-12 also increased
Kawanokuchi et al., Mult Scler 2006 : Stimulation of microglia with IL-12 and IL-18 resulted in MHC class II mRNA expression in microglia
Marshall et al., J Immunol 2008 (MAP Kinase Signaling System) : During this process, cells initiate proteolytic degradation of internalized protein Ags into peptides that complex with MHC class II (MHC II) and simultaneously increase expression of costimulatory molecules and of cytokines such as IL-6, IL-12 , and IL-23
Suemoto et al., J Dermatol Sci 1998 : The expression of MHC class II , CD80 and CD86 on EC was not affected by IL-12