◀ Back to MAPK6

HIF1A — MAPK6

Text-mined interactions from Literome

Liu et al., J Biol Chem 2002 (Anoxia...) : Finally, PGE ( 2 ) effects on HIF-1alpha were specifically inhibited by PD98059 ( a MAPK inhibitor )
Sang et al., J Biol Chem 2003 (Anoxia...) : We show that MAPK is required for the transactivation activity of HIF-1 alpha
Gao et al., Toxicol Appl Pharmacol 2004 (Ovarian Neoplasms) : To explore the mechanism of 4-OHE2 induced HIF-1alpha and VEGF-A expression, we studied whether phosphatidylinositol 3-kinase (PI3K) or mitogen activated protein kinase ( MAPK ) signaling pathways are involved in 4-OHE2 induced HIF-1alpha and VEGF-A expression
Murata et al., J Orthop Res 2006 (Anoxia...) : Both hypoxia and IL-1 induced HIF-1alpha were attenuated by p38 MAPK and JNK inhibitors
Carnesecchi et al., Exp Cell Res 2006 : We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha
Rezvani et al., J Biol Chem 2007 (Cell Transformation, Neoplastic) : Indeed, activation of p38 MAPK and JNK1 mediated by mitochondrial ROS were required for HIF-1alpha phosphorylation and accumulation after UVB irradiation
Zhang et al., Free Radic Biol Med 2007 : Activation of p38 MAPK and HIF-1alpha accumulation were attenuated by N-acetyl-L-cysteine ( antioxidant ), catalase ( hydrogen peroxide scavenger ), or a selective p38 MAPK inhibitor ( SB203580 )
Triantafyllou et al., Free Radic Biol Med 2008 (MAP Kinase Signaling System) : Localization of HIF-1alpha by immuno- and direct fluorescence microscopy and in vitro phosphorylation assays suggest that flavonoids inhibit HIF-1 activity by impairing the MAPK dependent phosphorylation of HIF-1alpha , thereby decreasing its nuclear accumulation
Gelse et al., Osteoarthritis Cartilage 2008 (Cartilage Diseases) : The functional role of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling on BMP-2/IGF-1 induced HIF-1alpha expression was assessed in vitro by employing specific inhibitors
Lin et al., Cell Physiol Biochem 2008 (Brain Ischemia...) : However, BAPTA-AM ( an intracellular calcium chelator ), SB 203580 ( an inhibitor of p38 ) and HIF-1alpha antisense significantly inhibited the [ Ca ( 2+ ) ] ( i ), p38 MAPK phosphorylation and HIF-1alpha expression respectively ... Our results also showed that p38 MAPK phosphorylation was reduced by BAPTA-AM, and HIF-1alpha expression was inhibited by SB203580 and BAPTA-AM, suggesting that calcium, p38 MAPK and HIF-1alpha are in the same signal transduction pathways during LOGD
Mori et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha
Kuo et al., Biochem Biophys Res Commun 2009 (Breast Neoplasms) : Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK ) signaling pathways are involved in TNFalpha mediated HIF-1alpha accumulation and activation under normoxic conditions
Sumbayev et al., Eur J Immunol 2009 : ERK and p38 MAPK , but not reactive oxygen species ( ROS ), ASK1 or PI 3-kinase, were critical for IgE mediated accumulation of HIF-1alpha , although the latter crucially affected degranulation
Shin et al., Toxicol In Vitro 2010 : Moreover, treatment with SP600125 or SB203580, but not PD98059, had partial inhibitory effects on the stability of HIF-1alpha protein induced by manganese, suggesting that p38 MAPK and JNK-1/2 also contribute to the Mn-mediated HIF-1alpha protein stability
Brant et al., Am J Respir Cell Mol Biol 2013 (Inflammation) : The Ni-induced HIF1A DNA binding was enhanced by PGE2 and mediated , in part, by activation of p38 MAPK