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HIC1 — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HIC1
—
SIRT1
(physical association, affinity chromatography technology)
Dehennaut et al., Biochem Biophys Res Commun 2012*
-
IRef Biogrid Interaction:
HIC1
—
SIRT1
(physical association, affinity chromatography technology)
Chen et al., Cell 2005*
-
IRef Biogrid Interaction:
HIC1
—
SIRT1
(colocalization, imaging technique)
Sun et al., J Natl Cancer Inst 2013*
-
IRef Biogrid Interaction:
HIC1
—
SIRT1
(physical association, affinity chromatography technology)
Dehennaut et al., J Biol Chem 2013*
-
IRef Biogrid Interaction:
HIC1
—
SIRT1
(physical association, affinity chromatography technology)
Stankovic-Valentin et al., Mol Cell Biol 2007*
-
IRef Hprd Interaction:
HIC1
—
SIRT1
(in vivo)
Chen et al., Cell 2005*
-
IRef Intact Interaction:
HIC1
—
SIRT1
(physical association, anti bait coimmunoprecipitation)
Chen et al., Cell 2005*
Text-mined interactions from Literome
Chen et al., Cell 2005
(Adenocarcinoma...) :
Tumor suppressor
HIC1 directly
regulates SIRT1 to modulate p53 dependent DNA-damage responses
Zhang et al., Proc Natl Acad Sci U S A 2007
:
Treatment with the glycolytic blocker 2-deoxyglucose ( 2-DG ) decreases association of the redox sensor CtBP with
HIC1 , an
inhibitor of
SIRT1 transcription
Huffman et al., Cancer Res 2007
(Prostatic Neoplasms) :
First, a transgenic mouse model of prostate cancer ( transgenic adenocarcinoma of mouse prostate ; TRAMP ) was used to determine the role of energy balance on
SIRT1 expression and the
effect of cancer stage on SIRT1 and
hypermethylated in cancer-1 (HIC-1)
Tseng et al., Neoplasia (New York, N.Y.) 2009
(Adenocarcinoma...) :
A HIC1-SIRT1-p53 circular loop in which
hypermethylation in cancer 1 (HIC1) represses the transcription of
SIRT1 that deacetylates and inactivates p53 thus leading to HIC1 inactivation has been identified in cell and animal models