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HGF — MAPK14

Text-mined interactions from Literome

Furukawa et al., Diabetologia 1999 : Hepatocyte growth factor induced sustained activation of the mitogen activated protein kinase , which was inhibited by PD098059
Day et al., Oncogene 1999 : HGF stimulated DNA synthesis in 184B5 and 32D/c-Met cells, while HGF/NK2 was mitogenically inactive, despite the ability of HGF/NK2 to stimulate c-Met autophosphorylation, mitogen activated protein kinase ( MAPK ), and phosphatidylinositol 3-kinase (PI3K) in both cell systems ... In 184B5 cells, HGF stimulated sustained MAPK activation, while activation by HGF/NK2 declined rapidly
Zhang et al., J Neurosci Res 2000 : HGF stimulated both mitogen activated protein ( MAP ) kinase and phosphatidylinositol-3 (PI3)-kinase activity in cerebellar granule neurons
Sergeant et al., J Biol Chem 2000 : In Huma 109 cells cultured on plastic, HGF/SF stimulated a transient phosphorylation of p42/44(MAPK) , which reached a maximum at 10 min after addition of the growth factor and returned to near basal levels after 20 min ... However, HGF/SF stimulated DNA synthesis and a sustained phosphorylation of p42/44(MAPK) in sulfated glycosaminoglycan-deficient Huma 109 cells plated on a substratum of medium HSPGs but not cell HSPGs
Nakagami et al., J Hypertens 2000 : In contrast, although p38MAPK was also phosphorylated by HGF , SB203580, a specific inhibitor of p38MAPK , failed to change the endothelial cell growth induced by HGF
Paumelle et al., Mol Biol Cell 2000 : We found that SF/HGF induces rapid and sustained phosphorylation of the extracellular signal regulated kinase ( ERK ) MAPK while stimulating weakly and then repressing phosphorylation of the JUN N-terminal kinase (JNK) MAPK for several hours
Fukujin et al., Biochem Biophys Res Commun 2000 : Furthermore, additivity of the signal transduction pathway of HGF/SF and EGF was investigated ( i.e., the activity of mitogen activated protein kinase ( MAPK ) induced by HGF/SF and EGF ), but it was not seen in PPH, PVH, or primary hepatocytes, although wortomannin, a PI 3-kinase inhibitor, abolished the additivity
Xiao et al., Proc Natl Acad Sci U S A 2001 (MAP Kinase Signaling System) : Mitogen activated protein kinase ( MAPK ) also is activated by HGF and rescues cells from apoptosis, although the cytoprotective effect is less marked than for PI3-kinase/Akt
Webster et al., Hepatology 2001 : Hepatocyte growth factor activated phosphoinositide 3-kinase dependent protein kinase B and mitogen activated protein kinase
Abounader et al., J Neurochem 2001 (Glioblastoma) : SF/HGF activated mitogen activated protein kinase ( MAPK ) and inhibition of either Ras or MAPK-kinase completely inhibited SF/HGF mediated c-met induction
Kitta et al., Free Radic Biol Med 2001 (MAP Kinase Signaling System) : HGF also activated MEK, p44/42 MAPK , and p90RSK
Kitta et al., Antioxid Redox Signal 2001 (MAP Kinase Signaling System) : This 2-min delay in HGF activation of MAPK resulted in > 5-min delay in phosphorylation of MAPK targets such as p90RSK and GATA-4 ... Thus, in cardiac myocytes, thiol antioxidants delay HGF mediated MAPK activation and suppress subsequent signaling eventsvia reactive oxygen species independent mechanism
Li et al., Oncogene 2001 (Melanoma) : All melanocytic cells expressed the HGF receptor c-Met, and autocrine HGF caused constitutive activation of c-Met, MAPK and PI3K
Delehedde et al., J Biol Chem 2002 : In human keratinocytes, HGF/SF stimulated DNA synthesis, and this was dependent on a sustained phosphorylation of p42/44(MAPK)
Chattopadhyay et al., Brain Res Mol Brain Res 2002 (Astrocytoma...) : PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells ... Moreover, a specific p38 MAPK inhibitor ( SB203580 ) almost completely inhibited basal HGF secretion to an undetectable level
Maejima et al., Atherosclerosis 2003 : ERK1/2 and p38 MAPK were phosphorylated by HGF and a MEK inhibitor PD98059 and a p38 MAPK inhibitor SB203580 inhibited HGF stimulated HUVEC growth by 66 % and by 58 % ; however, HGF induced phosphorylation of ERK1/2 and p38 MAPK was not inhibited by L-NAME, indicating that NO is not an upstream activator of ERK1/2 and p38 MAPK
Ogihara et al., J Biol Chem 2003 : p38 MAPK is involved in activin A- and hepatocyte growth factor mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells
Coltella et al., FASEB J 2003 (Bone Neoplasms...) : We analyzed the effect of the MET receptor activation in five human osteosarcoma cell lines evaluating the levels of HGF dependent activation of MAPK and PKB/AKT as biochemical readouts of mitogenic and invasive responses, respectively
Sengupta et al., Circulation 2003 : In a multichannel scratch assay with human endothelial cells ( ECs ), HGF/SF induced a strong and prolonged activation of MAPK and cell proliferation that was inhibited by PD98059 and LY294002/wortmannin, selective inhibitors of MAPK and PI3K signaling modules, respectively
Imayasu et al., Curr Eye Res 2003 : Western blot analysis of cultured corneal epithelial cells in rabbits showed phosphorylation of p44/42 MAPK after 30 minutes in response to KGF and HGF , whereas non activated p44/42 MAPK was ordinarily detected even at the absence of KGF or HGF
Lai et al., Oncogene 2004 (Carcinoma, Squamous Cell...) : Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of ERK/mitogen activated protein kinase ( MAPK ) signaling mediated by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF)
Yao et al., J Hepatol 2004 : We also observed activation of ERK1/2, p38 MAPK , Akt and NF-kappaB signaling pathways by HGF in WB-F344 cells
Halevy et al., Exp Cell Res 2004 (MAP Kinase Signaling System) : In contrast, MAPK/ERK phosphorylation was higher in response to HGF and lasted longer, relative to IGF-I ... Moreover, the finding that PI3K activity is required for HGF induced MAPK activation suggests its additional role in proliferation, rather than exclusively in the differentiation of adult myoblasts
Gwira et al., J Biol Chem 2005 : However, the simultaneous addition of Ngal and HGF leads to direct association of the two proteins, and results in a partial inhibition of HGF mediated activation of c-Met and the downstream MAPK and phosphatidylinositol 3-kinase signaling pathways
Coltella et al., Int J Cancer 2006 (Adenocarcinoma...) : In fact, p38 MAPK activity is stimulated by HGF and further increased by the combined treatment with HGF and either CDDP or PTX
Rousseau et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here we show that CXCL12, complement factor 5a ( C5a ), hepatocyte growth factor (HGF) and platelet derived growth factor (PDGF)-BB, which stimulate cell migration, also activate p38alpha MAPK
Cohen et al., Am J Physiol Lung Cell Mol Physiol 2006 : OSM induced HGF secretion was inhibited by PD-98059 ( a specific pharmacological inhibitor of ERK1/2 ), SB-203580 ( a p38 MAPK inhibitor ), and SP-600125 ( a JNK inhibitor ) by 70, 82, and 100 %, respectively, whereas basal HGF secretion was only inhibited by SP-600125 by 30 %
Kimura et al., J Pharmacol Sci 2007 : Activation of mitogen activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes ... We investigated the effects of alpha ( 1 ) - and beta ( 2 ) -adrenergic agonists on hepatocyte growth factor (HGF) stimulated mitogen activated protein kinase ( MAPK ) isoforms in primary cultures of adult rat hepatocytes ... The results show that HGF increased phosphorylation of p42 MAPK by 2.2-fold within 3 min ... The HGF induced MAPK activation was abolished by AG1478 treatment ( 10 ( -7 ) M ) ... The MEK ( MAPK kinase ) inhibitor PD98059 ( 10 ( -6 ) M ) completely inhibited the HGF dependent increase in MAPK activity ... Moreover, the cell-permeable cAMP analog, 8-bromo cAMP ( 10 ( -7 ) M ), and phorbol 12-myristate 13 acetate ( 10 ( -7 ) M ) potentiated HGF induced MAPK phosphorylation ... These results suggest that direct or indirect activation of both PKA and PKC represent a positive regulatory mechanism for stimulating MAPK induction by HGF
Makondo et al., Eur J Pharmacol 2008 : In addition, geldanamycin treatment did not enhance the HGF induced phosphorylation of Akt, ERK1/2 and p38MAPK
Stabile et al., Mol Cancer Ther 2008 (Lung Neoplasms...) : L2G7, a single potent anti-human HGF neutralizing monoclonal antibody, showed profound inhibition of human HGF induced phosphorylated mitogen activated protein kinase induction, wound healing, and invasion in lung tumor cells in vitro
Shukla et al., Am J Respir Cell Mol Biol 2009 (MAP Kinase Signaling System...) : HGF induced expression of Smad7, an inhibitor of TGF-beta signaling, in a mitogen activated protein kinase dependent manner
Uruno et al., Hypertens Res 2008 : Our data therefore indicate that the stimulatory effects of low-dose fluvastatin on the HGF induced angiogenesis are mediated by its inhibitory effects on p38 MAPK phosphorylation induced by HGF , which may result in the suppression of EC apoptosis
Nechemia-Arbely et al., J Hepatol 2011 : This cooperative effect correlated with greater resistance of HIL-6 than IL-6 to HGF mediated reduction of AKT activation, rather than changes in STAT3 or MAPK signaling, and was completely blocked by PI3K inhibition
Tan et al., FEBS Lett 2011 (Carcinoma, Hepatocellular...) : Forced expression of miR-198 decreased c-MET expression at both mRNA and protein levels and consequently diminished HGF induced phosphorylation of p44/42 MAPK in HCC cells
Park et al., Mol Biol Cell 2012 : Mer-specific neutralizing antibody, small interfering RNA ( siRNA ), and a recombinant Mer protein ( Mer/Fc ) inhibited HGF mRNA and protein expression, as well as activation of RhoA, Akt, and specific mitogen activated protein ( MAP ) kinases in response to apoptotic cells
Schneider et al., Fertil Steril 2013 (Endometriosis...) : miR-10b overexpression significantly down-regulated SDC1, reduced Matrigel invasiveness by 20 % and cell viability by 14 %, and decreased mitogen activated protein kinase activation in response to hepatocyte growth factor
Adachi et al., Hepatology 1996 : However, HGF induced mitogen activated protein kinase ( MAPK ) activation was not affected by both butanol and propranolol
Liang et al., Invest Ophthalmol Vis Sci 1998 : Effects of HGF , KGF, and kinase inhibitors on mitogen activated protein kinase ( MAPK ) activation were evaluated by western blot analysis and enzymatic assays ... Hepatocyte growth factor or KGF rapidly activated MAPK in corneal epithelial cells ... The activation of MAPK ( p42 and p44 ) by HGF or KGF was transient and decreased gradually within 1 hour ... Activation of MAPK induced by HGF was partially inhibited by protein kinase C inhibitor calphostin C. Hepatocyte growth factor and KGF had no effect on the activation of Jak-STAT cascade components that are activated by epidermal growth factor
Lee et al., J Biomed Sci 1998 (Carcinoma, Hepatocellular) : Hepatocyte growth factor stimulates the growth and activates mitogen activated protein kinase in human hepatoma cells