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AKT1 — HGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AKT1 → HGF (increases) Jagadeeswaran et al., Cancer Res 2006*
  Evidence: MPM cells were responsive to HGF (40 ng/mL) stimulation of c-Met signaling up to 5 hours in a time-dependent fashion (Fig. 2B). Significant induction of tyrosine phosphorylation in c-Met of the autophosphorylation site (pY1230/1234/1235) as well as the regulatory juxtamembrane c-Cbl binding site (pY1003) was evident starting at 15 minutes of HGF stimulation and the phospho-signal declined between 2 and 5 hours. Moreover, phosphorylation of ERK1/2 (pT185/pY187) and AKT (S473) was significantly in...
• OpenBEL Selventa BEL large corpus: AKT1 → HGF (increases) Ma et al., Br J Cancer 2007*
  Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...

Text-mined interactions from Literome

Liu et al., Am J Physiol 1999 : HGF induced rapid phosphorylation of Akt in HKC cells, which was immediately followed by phosphorylation and resultant inactivation of Bad, a pro-apoptotic member of the Bcl-2 family ... Pretreatment of the HKC cells with 10 nM wortmannin completely abolished HGF induced phosphorylation of Akt and Bad, suggesting that this pathway is dependent on phosphoinositide (PI) 3-kinase
Zhang et al., J Neurosci Res 2000 : HGF induced phosphorylation of Akt and pretreatment of the cells with wortmannin completely impaired Akt activation
Qiao et al., Cell Growth Differ 2000 (Carcinoma, Intraductal, Noninfiltrating...) : We now show in detached cells a cooperative effect of HGF and FN in the activation of PI 3-kinase and on the phosphorylation of PKB/Akt at serine 473 ... We now show in detached cells a cooperative effect of HGF and FN in the activation of PI 3-kinase and on the phosphorylation of PKB/Akt at serine 473
Coulonval et al., Biochem J 2000 : In contrast, phosphatidylinositol 3-kinase ( PI 3-kinase ) and protein kinase B (PKB) activation by insulin and HGF is strong and sustained, whereas it is weak and transient with EGF and absent in the presence of TSH or PMA
Fan et al., Oncogene 2000 (Breast Neoplasms...) : Consistent with this finding, HGF/SF induced the phosphorylation of c-Akt ( protein kinase-B ), a PI3K substrate implicated in apoptosis inhibition ; and an expression vector encoding a dominant negative kinase inactive Akt partially but significantly inhibited HGF/SF mediated cell protection and DNA repair
Bowers et al., Cancer Res 2000 (Glioblastoma...) : Phosphorylation of the cell survival promoting kinase Akt ( protein kinase B ) resulted from SF/HGF treatment of U373 cells, and both Akt phosphorylation and cell survival induced by SF/HGF were inhibited by phosphatidylinositol 3-kinase inhibitors but not by inhibitors of mitogen activated protein kinase kinase or protein kinase C. Cytoprotection by SF/HGF in vitro was also inhibited by transient expression of dominant negative Akt
Webster et al., Hepatology 2001 : Hepatocyte growth factor activated phosphoinositide 3-kinase dependent protein kinase B and mitogen activated protein kinase
Wick et al., J Neurosci 2001 (Disease Models, Animal...) : Furthermore, dominant negative ezrins block hepatocyte growth factor (HGF) mediated stimulation of clonogenicity and migration, without altering HGF induced protein kinase B/Akt and focal adhesion kinase phosphorylation ... Furthermore, dominant negative ezrins block hepatocyte growth factor (HGF) mediated stimulation of clonogenicity and migration, without altering HGF induced protein kinase B/Akt and focal adhesion kinase phosphorylation
De Lédinghen et al., Int J Oncol 2001 (Carcinoma, Hepatocellular...) : Moreover, trans-resveratrol did not decrease hepatocyte growth factor induced c-met autophosphorylation, or Akt-1 or extracellular regulated kinases-1 and -2 activation
Frasca et al., Oncogene 2001 (Thyroid Neoplasms) : The STI571 enhanced motile response can be correlated with an increase in the Met receptor tyrosine phosphorylation as well as ERK and Akt activation by HGF
Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : HGF induced phosphorylation of mitogen activated protein/extracellular signal regulated kinase kinase ( MEK ) pathway substrate p42/p44 ( erk ) and phosphatidylinositol 3'-kinase (PI3K) pathway substrate Akt provided evidence for downstream activation of MEK and PI3K pathways in HNSCC
Delehedde et al., Eur J Biochem 2001 : HGF/SF also induced an early increase in the phosphorylation of protein kinase B/Akt ... HGF/SF also induced an early increase in the phosphorylation of protein kinase B/Akt
Wajih et al., Circ Res 2002 : Conditioned medium containing soluble c-met inhibited the induction of Akt phosphorylation by HGF in HUVECs
Hossain et al., J Neurochem 2002 : Exposure to NMDA or QUIN for 24 h resulted in concentration dependent cell death ( p < 0.001 ) that was completely attenuated ( p < 0.001 ) by pre-treatment of cells with SF/HGF ( 50 ng/mL ) or FGF-1 ( 40 ng/mL ). SF/ HGF and FGF-1 activated both Akt and MAP-kinase > threefold ( p < 0.001 )
Yanai et al., Invest Ophthalmol Vis Sci 2002 : Basic fibroblast growth factor, keratinocyte growth factor, nerve growth factor, and hepatocyte growth factor stimulated cell proliferation but did not induce Akt activation or protect the cells from SNP induced apoptosis
Ma et al., Atherosclerosis 2002 (Arteriosclerosis) : HGF induced the phosphorylation of Akt and Erk1/2, cell survival factors, in a time dependent manner in serum deprived HUVEC
Taher et al., Biochem Biophys Res Commun 2002 (Arteriosclerosis...) : Stimulation with HGF led to activation of Met as well as to activation of PI3-K, PKB/Akt , MEK, and the MAP kinases Erk1 and -2 ... Stimulation with HGF led to activation of Met as well as to activation of PI3-K, PKB/Akt , MEK, and the MAP kinases Erk1 and -2
Sengupta et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System...) : We demonstrate that HGF/SF can induce angiogenesis independently of VEGF, possibly through the direct activation of the Akt and ERKs
Coltella et al., FASEB J 2003 (Bone Neoplasms...) : We analyzed the effect of the MET receptor activation in five human osteosarcoma cell lines evaluating the levels of HGF dependent activation of MAPK and PKB/AKT as biochemical readouts of mitogenic and invasive responses, respectively ... We analyzed the effect of the MET receptor activation in five human osteosarcoma cell lines evaluating the levels of HGF dependent activation of MAPK and PKB/AKT as biochemical readouts of mitogenic and invasive responses, respectively
Chan et al., J Biol Chem 2003 : Finally, the increased phosphorylation of Gab1 by Src selectively potentiated HGF induced activation of ERK and AKT
Okano et al., Biochem Biophys Res Commun 2003 : The activation of AKT , p70 ( s6k ), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen activated protein kinase/ERK kinase ( MEK ) inhibitor, respectively
Takeuchi et al., J Biol Chem 2004 : The protective effect of HGF/SF against the ADR induced apoptosis was abolished in the presence of either LY294002, an inhibitor of phosphatidylinositol-3'-OH kinase ( PI3-K ) or 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate, an inhibitor of Akt, thus implicating the activation of PI3-K-Akt signaling in the antiapoptotic action of HGF/SF. Immunoblotting analysis revealed that HGF/SF stimulated the sustained phosphorylation of Akt for several hours but that EGF stimulated the phosphorylation only transiently
Lai et al., Oncogene 2004 (Carcinoma, Squamous Cell...) : Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of ERK/mitogen activated protein kinase ( MAPK ) signaling mediated by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF)
Schulze-Bergkamen et al., Hepatology 2004 : PI3K/Akt activation by HGF results in the induction of antiapoptotic proteins such as Mcl-1
Taniguchi et al., Mol Reprod Dev 2004 (MAP Kinase Signaling System) : Here, we showed that HGF activated the distinct phosphorylation of Raf-1, MEK1/2, and ERK1/2, but did not induce phosphorylation of Akt
Yao et al., J Hepatol 2004 : We also observed activation of ERK1/2, p38 MAPK, Akt and NF-kappaB signaling pathways by HGF in WB-F344 cells
Warshamana-Greene et al., Mol Cancer Ther 2004 (Carcinoma, Small Cell...) : However, NVP-ADW742 affected neither hepatocyte growth factor mediated Akt activation nor activity of constitutively active Akt
Goda et al., J Gene Med 2004 (Cryptorchidism) : Adenovirus mediated HGF gene transfer induced overexpression of HGF in some seminiferous epithelial cells and interstitial cells, increased the phosphorylation of ERK and Akt , and decreased numbers of apoptotic cells of germ cells
Hov et al., Clin Cancer Res 2004 (Multiple Myeloma) : PHA-665752 effectively blocked the biological responses to HGF in all assays, with 50 % inhibition at 5 to 15 nmol/L concentration and complete inhibition at around 100 nmol/L. PHA-665752 inhibited phosphorylation of several tyrosine residues in c-Met ( Tyr ( 1003 ), Tyr ( 1230/1234/1235 ), and Tyr ( 1349 ) ), blocked HGF mediated activation of Akt and p44/42 mitogen activated protein kinase, and prevented the adaptor molecule Gab1 from complexing with c-Met
Uruno et al., Hypertens Res 2004 (MAP Kinase Signaling System) : HGF also stimulated Akt phosphorylation ( Ser-473 ), which was completely suppressed by LY294002 and was partially suppressed by U0126
Tjin et al., Blood 2006 (Lymphoma, B-Cell...) : In MET positive DLBCL cells, HGF induces MEK dependent activation of ERK and PI3K dependent phosphorylation of PKB , GSK3, and FOXO3a
Jagadeeswaran et al., Cancer Res 2006 (Mesothelioma...) : There was a differential growth response and activation of AKT and extracellular signal regulated kinase 1/2 in response to HGF for the various cell lines
Bigelow et al., Oncogene 2006 (Breast Neoplasms...) : HGF treatment in both cell lines induced rapid, sustained activation of Met, ERK and AKT ... Pretreatment of cells with concentrations of EGCG as low as 0.3 microM inhibited HGF induced Met phosphorylation and downstream activation of AKT and ERK ... ( - ) -Epigallocatechin ( EGC ), however, completely repressed HGF induced AKT and ERK phosphorylation at concentrations of 10 and 20 microM, but was incapable of blocking Met activation
Lee et al., Chem Biol Interact 2006 (Carcinoma, Hepatocellular...) : In addition, Western blotting and immunoprecipitation were performed to confirm luteolin suppressed the phosphorylation of c-Met, the membrane receptor of HGF, as well as ERK1/2 and Akt , but not JNK1/2, which is activated by HGF
Gong et al., Kidney Int 2006 (Acute Disease...) : HGF activated phosphatidylinositol 3-kinase (PI3K)-Akt that in turn inhibited its downstream transducer glycogen synthase kinase ( GSK ) 3
Ishibe et al., Mol Cell Biol 2006 : In contrast, confluent cells, in which HGF stimulated Akt activation was diminished, displayed less inhibitory phosphorylation of GSK-3beta and less nuclear signaling by beta-catenin
Rush et al., Exp Cell Res 2007 (MAP Kinase Signaling System) : HGF also activated AKT , while inhibition of AKT by LY294002 induced a modest decrease of HGF induced HBMEC migration
Bertola et al., J Biol Chem 2007 (Insulin Resistance) : In adipocytes rendered insulin-resistant by a long lasting tumor necrosis factor alpha treatment, the protein level of Gab1 was strongly decreased, and HGF stimulated PKB activation and glucose uptake were also altered
Zhang et al., Chin Med J (Engl) 2007 (Colorectal Neoplasms...) : Hepatocyte growth factor induced phosphorylation of c-Met, ERK1/2 and AKT in a dose dependent manner
Wang et al., Cancer Lett 2007 (Neoplasm Invasiveness...) : CHM-1 also suppressed HGF induced Akt phosphorylation, and NF-kappaB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9
Ramos-Nino et al., Am J Respir Cell Mol Biol 2008 (Mesothelioma) : In three of seven human MM lines evaluated, HGF increased Fra-1 levels and phosphorylation of both extracellular signal regulated kinase 5 ( ERK5 ) and AKT that were inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY290042
He et al., Colloids Surf B Biointerfaces 2008 : HGF stimulated both ERK1/2 and Akt activities in cortical neurons
Lee et al., Toxicol Appl Pharmacol 2008 (Breast Neoplasms...) : The effect of apigenin on HGF induced signaling activation involving invasive growth was evaluated by immunoblotting analysis, it shows that apigenin blocks the HGF induced Akt phosphorylation but not Met, ERK, and JNK phosphorylation ... In addition to MDA-MB-231 cells, apigenin exhibits inhibitory effect on HGF induced Akt phosphorylation in hepatoma SK-Hep1 cells and lung carcinoma A549 cells
Makondo et al., Eur J Pharmacol 2008 : In addition, geldanamycin treatment did not enhance the HGF induced phosphorylation of Akt , ERK1/2 and p38MAPK
Lee et al., Am J Physiol Lung Cell Mol Physiol 2008 : Adenovirus mediated gene transfer of a dominant negative ( DN ) Akt mutant revealed that HGF increased COX-2 mRNA in an Akt dependent manner ... Inhibition of p42/p44 MAPK pathway blocked HGF mediated activation of beta-catenin gene transcription but not Akt activation, suggesting that p42/p44 MAPK acts in a parallel mechanism for beta-catenin activation
Lim et al., Cell Signal 2008 : Consistent with these results, HGF activated Akt , which phosphorylates glycogen synthase kinase-3beta ( GSK-3beta ) to inactivate it, and reduced phosphorylation of microtubule associated protein 2 (MAP2), which can promote microtubule polymerization and dendrite elongation when dephosphorylated ... Conversely, pharmacological inhibition of c-Met with its specific inhibitor, PHA-665752, or genetic knock-down of c-Met with short hairpin RNAs ( shRNAs ) suppressed HGF induced phosphorylation of Akt and GSK-3beta, increased phosphorylation of MAP2, and reduced dendrite number and length in cultured hippocampal neurons
Tam et al., J Mol Biol 2009 : In MDA-MB435 cells, HB10 reduced HGF dependent Met phosphorylation by 70 %, and phosphorylation of downstream kinases AKT and ERK1/ERK2 by 74 % and 69 %, respectively
Labbé et al., J Nutr 2009 (Medulloblastoma) : Furthermore, quercetin and kaempferol also strongly diminished HGF mediated Akt activation
Yu et al., Mol Biol Rep 2010 : Furthermore, our experiments suggest that HGF increases the level of phosphorylated Akt in EPCs rather than Akt ... However, PI3K inhibitor reduces the increase of phosphorylated Akt level induced by HGF
Azuma et al., Biomaterials 2010 : Immobilized AeHGF-Fc continuously activated Akt in HepG2 cells whereas Akt activation induced by soluble HGF rapidly decreased with time, indicating that immobilized AeHGF-Fc follows different signal transduction pathways compared to soluble HGF
Tan et al., J Biol Chem 2010 : Studies of isolated Appl1 ( -/- ) murine embryonic fibroblasts ( MEFs ) showed that Akt activation by epidermal growth factor, insulin, or fetal bovine serum was similar to that observed in wild-type MEFs, although Akt activation by HGF was diminished in Appl1 ( -/- ) MEFs
Goodwin et al., Cancer Res 2010 (Glioma) : Cyr61 mediates hepatocyte growth factor dependent tumor cell growth, migration, and Akt activation ... The effect of Cyr61 on HGF induced Akt pathway activation was also examined ... Cyr61 siRNA had no effect on the early phase of HGF induced Akt phosphorylation ( Ser ( 473 ) ) 30 minutes after stimulation with HGF
Zhou et al., Int J Cancer 2011 (Neoplasms) : The FLNA-deficiency specifically attenuated the activation of the c-MET downstream signaling molecule AKT in response to HGF stimulation
Dai et al., Mol Cancer Ther 2010 (Neoplasm Invasiveness...) : Mechanistically, nanomolar doses of BMS-777607 potently blocked HGF stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal regulated kinase
Duhon et al., Mol Carcinog 2010 (Prostatic Neoplasms) : EGCG added up to 4 h after the addition of HGF still blocked cell scattering and reduced the HGF induced phosphorylation of c-Met, Akt , and Erk, suggesting that EGCG could act both by preventing activation of c-Met by HGF and by attenuating the activity of pathways already induced by HGF
Nechemia-Arbely et al., J Hepatol 2011 : This cooperative effect correlated with greater resistance of HIL-6 than IL-6 to HGF mediated reduction of AKT activation, rather than changes in STAT3 or MAPK signaling, and was completely blocked by PI3K inhibition
Watanabe et al., Pancreas 2011 (Pancreatic Neoplasms) : Phosphorylation of Akt was induced by HGF , and the phosphorylated Akt persisted even when E-cadherin was inhibited
Agustian et al., Am J Pathol 2011 (Glomerulosclerosis, Focal Segmental) : In vitro, HGF stimulation of podocytes resulted in antiapoptotic phosphorylation of AKT and extracellular signal regulated kinase ( ERK ) and induction of X-linked inhibitor of apoptosis protein ( XIAP )
da Silva et al., J Cell Physiol 2012 (Inflammation) : Upstream, HGF led to robust and sustained AKT activation, which was required for p65 phosphorylation and A20 upregulation
Nasrazadani et al., Genes & cancer 2011 : In vitro, knockdown of JNK2 or GAB2 inhibits Akt activation by hepatocyte growth factor (HGF) , insulin, and heregulin-1, while phosphorylation of ERK is constitutive and Src dependent
Lei et al., Arch Dermatol Res 2012 : HGF could promote the expressions of p-AKT1/2/3 , p-ERK, p-GSK3ß, p-IKBa, and ß-catenin
Kim et al., Exp Cell Res 2011 : These results suggest that a-syntrophin is required for HGF induced migration of myoblasts and for proper PI3-kinase/Akt signaling
Brusevold et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In the E10 cell line, EGF and HGF induced phosphorylation of EGF receptor (EGFR) and Met, respectively, phosphorylation of ERK1/2, p38 and Akt , and dose dependent activation of cell migration
Huang et al., Carcinogenesis 2012 (Breast Neoplasms...) : HGF induced expression of LEF1 through phosphatidylinositol 3-kinase/Akt and nuclear factor-kappa B ( NF-?B ) signaling
Chen et al., PloS one 2012 : Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt , c-Src, and AP-1 signaling pathway ... Stimulation of osteoblasts with HGF enhanced PI3K, Akt , and c-Src activation
Park et al., Mol Biol Cell 2012 : Mer-specific neutralizing antibody, small interfering RNA ( siRNA ), and a recombinant Mer protein ( Mer/Fc ) inhibited HGF mRNA and protein expression, as well as activation of RhoA, Akt , and specific mitogen activated protein ( MAP ) kinases in response to apoptotic cells
Muñoz et al., Mol Cancer Res 2012 : In HepG2 cells, HGF ( 25 ng/mL ) significantly increases the ratio of SV1/KLF6 full by 40 % through phosphorylation of Akt and subsequent downregulation of two splicing regulators, SRSF3 ( SRp20 ) and SRSF1
Meyer et al., Frontiers in physiology 2012 : Interestingly, we observed that the HGF mediated AKT responses at the level of individual cells is rather heterogeneous
Bonanno et al., Journal of translational medicine 2012 (Multiple Myeloma) : Notably, HGF levels were higher within the BM microenvironment of patients with IDO+ myeloma disease compared with patients having IDO- MM. Mechanistically, the antagonism of MET receptor for HGF with SU11274, a MET inhibitor, prevented HGF induced AKT phosphorylation in MM cells and translated into reduced IDO protein levels and functional activity