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HEY2 — NOTCH4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Donovan et al., Curr Biol 2002
(Heart Defects, Congenital...) :
These results establish Hey2 as an important regulator of cardiac morphogenesis and suggest a
role for
Hey2 in mediating or modulating
Notch signaling in the developing heart
Havrda et al., Thromb Haemost 2006
:
Activation of Notch1 and
Notch4 induced the VSMC-selective target genes HRT1 and
HRT2 , promoted cell cycle transit in smooth muscle cells, and led to loss of density dependent growth inhibition
Rowlinson et al., Blood 2010
:
Whereas knockdown of
Hey2 expression
results in a loss of
Notch receptor expression in dorsal aorta angioblasts, activation of Notch signaling in hey2 morphants rescues HSC formation in zebrafish embryos