Gene interactions and pathways from curated databases and text-mining

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CXCR4 — HDAC8

Text-mined interactions from Literome

Mori et al., Cancer Res 2005 (Melanoma...) : In summary, a histone deacetylase inhibitor and a demethylating agent up-regulated CCR7 and CXCR4 expression on melanoma cells
Gul et al., Stem Cells Dev 2009 : We hypothesized that in HSPCs the CXCR4 receptor is regulated through chromatin remodeling by histone deacetylase inhibitors ( HDIs ) such as valproic acid ( VPA )
Gul et al., Leuk Res 2010 (Leukemia...) : We recently reported that the histone deacetylase inhibitor, valproic acid ( VPA ), increases CXCR4 receptor expression and function in cord blood hematopoietic stem/progenitor cells ( HSPC ) and the immature, highly CD34 positive AML cell lines KG-1a and KG-1