Gene interactions and pathways from curated databases and text-mining

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CASP7 — HDAC4

Text-mined interactions from Literome

Liu et al., J Biol Chem 2004 : HDAC4 degradation was not dependent on proteasome or CRM1 mediated export activity but instead was caspase dependent and was detectable in diverse human cancer lines
McCourt et al., Clin Cancer Res 2012 (Prostatic Neoplasms) : The histone deacetylase inhibitors ( HDACi ) , droxinostat and SAHA, also downregulated c-FLIP expression, induced caspase-8- and caspase-3/7 mediated apoptosis, and increased apoptosis in bicalutamide treated cells