Gene interactions and pathways from curated databases and text-mining

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CHUK — HDAC3

Text-mined interactions from Literome

Hoberg et al., Mol Cell Biol 2006 : Introduction of nonphosphorylatable mutants of RelA/p65 and SMRT proteins or the inhibition of IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Gloire et al., J Biol Chem 2007 : Further molecular studies demonstrated that the removal of chromatin bound HDAC3 , a histone deacetylase inhibiting p65 DNA binding, is differentially regulated by IKKalpha in a promoter-specific manner ... Indeed, whereas the absence of IKKalpha induces HDAC3 recruitment and repression on the icam-1 promoter, it has an opposite effect on the ikappabalpha promoter, where a better p65 binding occurs