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CREB1 — HDAC1

Pathways - manually collected, often from reviews:

• FastForward regulation: CREB1 → HDAC1 (transcriptional regulation, unknown) Zhang et al., Proc Natl Acad Sci U S A 2005
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC1 — CREB1 (physical association, affinity chromatography technology) Canettieri et al., Nat Struct Biol 2003*
• IRef Biogrid Interaction: HDAC1 — CREB1 (direct interaction, pull down) Canettieri et al., Nat Struct Biol 2003*
• IRef Biogrid Interaction: HDAC1 — CREB1 (physical association, affinity chromatography technology) Kim et al., Cell Mol Life Sci 2010*

Text-mined interactions from Literome

Michael et al., Mol Cell Biol 2000 : Rather, HDAC inhibitors augment CREB activity during the late attenuation phase by prolonging CREB phosphorylation on chromosomal but, remarkably, not on extrachromosomal templates
Canettieri et al., Nat Struct Biol 2003 : Here we show that HDAC1 associates with and blocks Ser133 phosphorylation of CREB during pre-stimulus and attenuation phases of the cAMP response
Lu et al., J Biol Chem 2003 : Although inhibition of histone deacetylase activity results in an increase of CREB- or CBP mediated gene expression, mutation of all three putative acetylation sites in the CREB activation domain markedly enhances the ability of CREB to activate a cAMP-responsive element dependent reporter gene