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HAVCR2 — IL12A

Text-mined interactions from Literome

Zhang et al., J Leukoc Biol 2012 : Blocking Tim-3 signaling or silencing Tim-3 expression led to a significant increase in TLR mediated IL-12 production, as well as a decrease in activation induced up-regulation of the immunoinhibitor, PD-1 ; TNF-a production was not altered significantly, but IL-10 production was increased
Yang et al., J Clin Invest 2012 (Lymphoma, Follicular) : IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
Wang et al., J Virol 2013 (Hepatitis C, Chronic) : We found that Tim-3 and IL-23p19 are highly expressed and that IL-12p35 is inhibited in human CD14 ( + ) monocytes, while IL-17 expression is upregulated in CD4 ( + ) T cells, in chronically HCV infected individuals compared to healthy subjects ... Our findings suggest that Tim-3 mediated differential regulation of IL-12/IL-23 drives TH17 cell development, a milieu favoring viral persistence and autoimmune phenomenon during HCV infection