Osawa et al., Biochem Biophys Res Commun 2013
(Genomic Instability...) :
However, the role of Arf in control of H2AX expression and genome stability is still unclear ... Here, we show that both Arf and p53 are required for the down-regulation of H2AX and formation of the growth arrested state
Atsumi et al., J Biol Chem 2013
:
Here we show that Arf/p53 dependent down-regulation of H2AX induced the selective survival of normal cells after drug treatment, resulting in the preferential targeting of cancer cells