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CASP7 — GZMB

Pathways - manually collected, often from reviews:

• BioCarta caspase cascade in apoptosis: ccp1 proteinase (GZMB) → Caspase 7 (CASP7) (modification, activates)
• BioCarta caspase cascade in apoptosis: ccp1 proteinase (GZMB) → Caspase 7 (active) (CASP7) (modification, activates)
  
• BioCarta apoptotic dna-fragmentation and tissue homeostasis: ccp1 proteinase (GZMB) → Caspase 7 (CASP7) (degradation, activates)
• NCI Pathway Database Caspase Cascade in Apoptosis: Granzyme B (GZMB) → Caspase 7 (CASP7) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: GZMB — CASP7 Scott et al., EMBO J 2005*
• IRef Bind_translation Interaction: GZMB — CASP7 (experimental interaction detection) Scott et al., EMBO J 2005*
• IRef Hprd Interaction: CASP7 — GZMB (in vitro) Gu et al., J Biol Chem 1996*
• IRef Innatedb Interaction: GZMB — CASP7 (unknown, -) Adrain et al., J Biol Chem 2005*
• IRef Innatedb Interaction: GZMB — CASP7 (unknown, -) Cullen et al., J Cell Biol 2007*
• IRef Innatedb Interaction: GZMB — CASP7 (unknown, -) Cullen et al., J Biol Chem 2009*
• IRef Innatedb Interaction: GZMB — CASP7 (unknown, -) Scott et al., EMBO J 2005*

Text-mined interactions from Literome

Tepper et al., Blood 1999 (Burkitt Lymphoma) : The apoptotic pathway distal to the DISC is intact because ceramide analogs, staurosporine, and granzyme B activate caspase-3 and induce apoptosis
Pathan et al., J Biol Chem 2001 (Neoplasms) : TUCAN interferes with binding of Apaf1 to procaspase-9 and suppresses caspase activation induced by the Apaf1 activator, cytochrome c. Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1/caspase-9 dependent stimuli, including Bax, VP16, and staurosporine, but not by Apaf1/caspase-9 independent stimuli, Fas and granzyme B
Jerome et al., J Immunol 2001 : In contrast, caspase 3 activation in mitochondria-free cell lysates by granzyme ( gr ) B was inhibited equivalently by Us5 deletion and rescue viruses, suggesting that gJ is not required for HSV to inhibition this process
Goping et al., Immunity 2003 : Thus granzyme B mediates direct cleavage of caspase 3 and also activates mitochondrial disruption, resulting in the release of proapoptotic proteins that suppress caspase inhibition
Fellows et al., Blood 2007 : Although GzmH is most closely related to the caspase activating granzyme B (GzmB) , neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme
Gu et al., J Biol Chem 1996 : The cleavage and activation of CMH-1 by granzyme B in vitro sugge st that, in addition to CPP32, CMH-1 may also play a role in CTL mediated cell killing
Chinnaiyan et al., Curr Biol 1996 : Here we report that granzyme B also activates ICE-LAP3/Mch3/CMH-1 ( referred to here as ICE-LAP3 ), which, along with Yama and Mch2, forms a subset of the ICE/CED-3 family of cysteine proteases most closely related to the Caenorhabditis elegans cell death gene, CED-3
Zapata et al., J Biol Chem 1998 : Since the granzyme B is a direct activator of caspase-3 and its expression is induced following T-cell activation, we tested the effects of anti-GraB, an engineered serpin that specifically inhibits GraB