Gene interactions and pathways from curated databases and text-mining

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GYS1 — PRKAR2A

Text-mined interactions from Literome

Filippa et al., Mol Cell Biol 1999 : We looked at events downstream of PKB and found that PKA activation of PKB led to the phosphorylation and inhibition of glycogen synthase kinase-3 ( GSK-3 ) activity, a known in vivo substrate of PKB
Liu et al., J Mol Neurosci 2011 : To further understand the anti-inflammatory effect of adenosine cyclic 3',5'-monophosphate ( cAMP ), we examined the effect of protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor ( Epac ) on the transcription and production of cytokines and on the activity of mitogen activated protein kinases ( MAPK ) p38 and glycogen synthase kinase-3ß ( GSK-3ß ) in endotoxin treated rat primary cultured microglia
Maldonado et al., Cancer Res 2010 (Carcinoma, Hepatocellular...) : Protein kinase A (PKA) activation by cAMP analogues and glycogen synthase kinase 3ß ( GSK-3ß ) inhibition decreased d?, whereas PKA inhibition hyperpolarized, consistent with reports that PKA and GSK-3ß decrease and increase VDAC conductance, respectively