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CASP5 — GSN
Text-mined interactions from Literome
Li et al., Transfusion 2000
:
Platelets contain many of the components of the apoptotic mechanism and show
activation of
caspase 3 and consequent cleavage of
gelsolin during storage, independent of platelet activation
Boccellino et al., J Cell Physiol 2004
(Carcinoma, Squamous Cell...) :
Apoptosis induced by interferon-alpha and antagonized by EGF is regulated by
caspase-3 mediated cleavage of
gelsolin in human epidermoid cancer cells ... In conclusion, our data are the first demonstration that IFNalpha can induce morphological cell changes that are peculiar of apoptosis onset through the
caspase-3 mediated cleavage of
gelsolin
Leifeld et al., Am J Pathol 2006
(Liver Failure) :
Therefore, we studied an in vivo model of hepatic failure by analyzing expression of
gelsolin ; intrahepatic
activation of
caspase-3 , -8, and -9 ; and the extent of apoptosis in gelsolin knockout ( gsn ( -/- ) ) versus wild-type mice ( gsn ( +/+ ) ) after exposure to stimulatory Fas antibody Jo-2
Mani et al., Am J Physiol Heart Circ Physiol 2008
(Cardiomegaly...) :
Calpeptin blocked the following PO-induced changes : calpain enrichment and activation, decreased calpastatin level,
caspase-3 activation , enrichment and cleavage of
gelsolin , TUNEL staining, and histone H2B phosphorylation
Kothakota et al., Science 1997
:
Gelsolin was cleaved in vivo in a
caspase dependent manner in cells stimulated by Fas