Gene interactions and pathways from curated databases and text-mining

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GSK3B — NOTCH4

Text-mined interactions from Literome

Espinosa et al., J Biol Chem 2003 : Consistent with this, GSK-3 beta inhibits the transcriptional activation of Notch target genes both in vitro and in vivo, whereas lithium chloride treatment or Wnt-1 overexpression that results in GSK-3 beta inhibition leads to the up-regulation of the Hes-1 promoter ... Together, our results suggest that cross-talk between Notch and Wnt pathways may be partially mediated by specific regulation of GSK-3 beta dependent Notch phosphorylation
Guha et al., Basic Res Cardiol 2011 (Neointima) : Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells : role in cell proliferation and survival