Gene interactions and pathways from curated databases and text-mining

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CASP7 — GRP

Text-mined interactions from Literome

Lin et al., Anticancer Res 2007 (Nasopharyngeal Neoplasms) : Moreover, for the first time in NPC cells it was demonstrated that the pathway involved in rhein induced apoptosis is caspase dependent, presumably through the endoplasmic reticulum ( ER ) stress pathway, as shown by an increase in the levels of glucose regulated protein 78 (GRP 78) , PKR-like ER kinase (PERK), activating transcription factor 6 ( A TF6 ) and CCAA TIenhancer binding protein homologous protein ( CHOP ) as well as the activation of caspase-3 , -8, -9 and -12
Barateiro et al., Neuromolecular Med 2012 : Our results show that OPC display increased apoptosis and necrosis-like cell death upon UCB exposure, mediated by early signals of endoplasmic reticulum ( ER ) stress [ e.g. upregulation of glucose regulated protein (GRP)78 , inositol requiring enzyme ( IRE ) -1a and activation transcription factor (ATF)-6, as well as activation of caspase-2 and c-Jun N-terminal kinase (JNK) ], followed by mitochondrial dysfunction ( e.g. loss of mitochondria membrane potential and caspase-9 activation )