Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

GRB2 — IGF1

Pathways - manually collected, often from reviews:

  • BioCarta multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta/14-3-3 complex (IGF1R-YWHAH-IGF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta the igf-1 receptor and longevity: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta igf-1 signaling pathway: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta nfat and hypertrophy of the heart : RAS activating ligand/RAS activating receptor complex (IGF1_HBEGF_LIF_ALOX15B_CTF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GTP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1 complex (GRB2-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
    Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)

Text-mined interactions from Literome

Ariga et al., Biochem J 2000 : Under these conditions, cAMP pretreatment significantly increased binding of Grb2 ( growth-factor-receptor bound protein 2 ) to Shc in response to IGF-I , and activation of MAP kinase ( mitogen activated protein kinase ) induced by IGF-I was also enhanced by cAMP
Mincione et al., Exp Cell Res 2003 : Conversely, TGF-beta 1 did not alter IGF-I stimulated IRS-1 associated phosphatidylinositol 3-kinase activity, IGF-I induced tyrosine phosphorylation of Shc, and its binding to Grb2
Massicotte et al., Arthritis Res Ther 2006 (Osteoarthritis) : The interaction of Grb2 with IRS-1 progressively increased in response to IGF-1 in OA Obs whereas this was absent in normal Ob. IGF-1 stimulation altered alkaline phosphatase in Ob, an effect reduced in the presence of PD98059, an inhibitor of p42/44 MAPK signaling, whereas neither IGF-1 nor PD98059 had any significant effect on collagen synthesis
Shen et al., J Biol Chem 2010 : A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I
Valverde et al., Mol Endocrinol 1998 : Furthermore, insulin/IGF-I stimulated IRS-1 associated Grb-2 phosphorylation
Hügl et al., J Biol Chem 1998 : Glucose and IGF-I also induced Shc association with Grb2/mSOS
Kim et al., J Biol Chem 1998 (Neuroblastoma) : In the current study, we report that IGF-I induces a sustained tyrosine phosphorylation of Shc and its association with Grb2 in SH-SY5Y human neuroblastoma cells ... In contrast, IGF-I induces a transient tyrosine phosphorylation of IRS-2 and an association of IRS-2 with Grb2 ... In contrast, IGF-I induces a transient tyrosine phosphorylation of IRS-2 and an association of IRS-2 with Grb2