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GRB10 — IGF1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → GRB10 (GRB10) (modification, collaborate) Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) (modification, collaborate)
  Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: GRB10 (GRB10) → IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) (modification, collaborate)
  Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) → SHC (SHC1) (modification, collaborate) Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Lopaczynski et al., Acta biochimica Polonica 1999 : These studies raise the possibility that 14-3-3 and Grb10 may play a role in insulin and IGF-I signal transduction and may underlie the observed differences
Wang et al., Mol Cell Biol 1999 : ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I , and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion ... ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I , and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion
Giovannone et al., J Biol Chem 2003 : Stimulation with IGF-I results in increased binding of GIGYF1 to Grb10 and transient binding of both Grb10 and GIGYF1 to IGF-I receptors, presumably via the adapter function of Grb10
Morrione et al., J Cell Physiol 2003 : Many recent reports have suggested a very important role of Grb10 in regulating IGF-IR signaling ... In this review, we will focus on the role of Grb10 in IGF-I induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand induced ubiquitination, internalization, and stability of the IGF-IR
Monami et al., J Cell Physiol 2008 : We have shown that Grb10 binds the E3 ubiquitin ligase Nedd4 and promotes IGF-I stimulated ubiquitination, internalization, and degradation of the IGF-IR , thereby giving rise to long-term attenuation of signaling
Huang et al., J Biol Chem 2010 : In addition to inhibiting insulin receptor and IGF1R kinase activity by directly binding to the receptors, GRB10 can also negatively regulate insulin and IGF1 signaling by mediating insulin receptor and IGF1R degradation through ubiquitination