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AKT1 — GPS2

Text-mined interactions from Literome

Lefebvre et al., Mol Endocrinol 2006 : Through direct phosphorylation of the corepressor silencing mediator for retinoic and thyroid hormone receptors ( SMRT ), Akt stabilized RAR/SMRT interaction, leading to an increased tethering of SMRT to the RARbeta2 promoter, decreased histone acetylation, down-regulation of the RARbeta2 expression, and impaired cellular differentiation in response to retinoid
Furuya et al., Mol Cell Biol 2007 (Thyroid Neoplasms) : Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells led to overactivated p-AKT and increased cell proliferation and motility
Furuya et al., Steroids 2009 (Thyroid Neoplasms) : Over-expression of NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over activated PI3K-AKT signaling to increase cell proliferation and motility