Gene interactions and pathways from curated databases and text-mining

◀ Back to TLR4

GPI — TLR4

Text-mined interactions from Literome

Krishnegowda et al., J Biol Chem 2005 (Inflammation) : The data show that GPI signaling is mediated mainly through recognition by TLR2 and to a lesser extent by TLR4
Laplante et al., J Biol Chem 2011 : We hypothesized that, like other endogenous TLR ligands, ß ( 2 ) GPI interacts specifically with LPS and that this interaction is responsible for apparent TLR4 activation by ß ( 2 ) GPI ... Here, we show that both LPS and TLR4 are required for ß ( 2 ) GPI to bind to and activate macrophages
Allen et al., Blood 2012 (Thrombosis) : In the present study, we confirm a critical role for TLR4 in anti-ß ( 2 ) GPI Ab-mediated EC activation and demonstrate that signaling through TLR4 is mediated through the assembly of a multiprotein signaling complex on the EC surface that includes annexin A2, TLR4, calreticulin, and nucleolin