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GPI — TLR4
Text-mined interactions from Literome
Krishnegowda et al., J Biol Chem 2005
(Inflammation) :
The data show that
GPI signaling is
mediated mainly through recognition by TLR2 and to a lesser extent by
TLR4
Laplante et al., J Biol Chem 2011
:
We hypothesized that, like other endogenous TLR ligands, ß ( 2 ) GPI interacts specifically with LPS and that this interaction is responsible for apparent
TLR4 activation by ß ( 2 )
GPI ... Here, we show that both LPS and
TLR4 are
required for ß ( 2 )
GPI to bind to and activate macrophages
Allen et al., Blood 2012
(Thrombosis) :
In the present study, we confirm a critical
role for
TLR4 in anti-ß ( 2 )
GPI Ab-mediated EC activation and demonstrate that signaling through TLR4 is mediated through the assembly of a multiprotein signaling complex on the EC surface that includes annexin A2, TLR4, calreticulin, and nucleolin