◀ Back to AKT1
AKT1 — GP6
Text-mined interactions from Literome
Barry et al., J Biol Chem 2002
:
Protein kinase B is
regulated in platelets by the collagen receptor
glycoprotein VI ... Here we have examined the
regulation of
protein kinase B (PKB) , a downstream effector of PI3K, by the platelet collagen receptor
glycoprotein (GP) VI and thrombin receptors
Xiong et al., J Cell Physiol 2009
:
Dystrophin
glycoprotein complex associated Gbetagamma subunits
activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin dependent manner
Kim et al., J Biol Chem 2009
:
Thus, we investigated the contribution of PI3K isoforms to
GPVI mediated platelet activation and
Akt activation ... A protein kinase C inhibitor GF 109203X or a P2Y ( 12 ) receptor antagonist AR-C69931MX partly reduced
GPVI induced
Akt phosphorylation ... Platelets from mice dosed with clopidogrel also showed partial Akt phosphorylation, indicating that
GPVI mediated
Akt phosphorylation is regulated by both secretion dependent and -independent pathways ... In addition,
GPVI induced
Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI ... These results demonstrate that
GPVI induced
Akt activation in platelets is dependent in part on G ( i ) stimulation through P2Y(12) receptor activation by secreted ADP ... In addition, a significant portion of GPVI dependent, ADP independent Akt activation also exists, and PI3Kbeta plays an essential role in
GPVI mediated platelet aggregation and
Akt activation
Oh et al., J Biol Chem 1998
:
Activation of phosphatidylinositol 3-kinase through
glycoprotein 130
induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes