Gene interactions and pathways from curated databases and text-mining

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AKT1 — GNRH2

Text-mined interactions from Literome

Mutiara et al., Mol Cell Endocrinol 2008 : Using the well differentiated, clonal gonadotroph cell line, LbetaT2, we examined ( 1 ) whether Akt/PKB was activated by gonadotropin releasing hormone (GnRH) ; ( 2 ) the contribution of PI3-kinase-Akt/PKB pathway in each of gonadotropin subunit gene expression ; ( 3 ) crosstalk between extracellular signal regulated kinase ( ERK ) and Akt/PKB pathways
Zhao et al., Zhonghua Fu Chan Ke Za Zhi 2009 (Endometrial Neoplasms) : Triptorelin and GnRH-II inhibited the Akt and ERK1/2 activity in the endometrial carcinoma cells
Ling Poon et al., Endocrinology 2011 (Ovarian Neoplasms) : In our studies of OVCAR-3 and CaOV-3 ovarian cancer cell lines, GnRH-II treatment induced phosphorylation of Akt and glycogen synthase kinase ( GSK ) 3ß, as well as ß-catenin accumulation in the nucleus, and the latter was reduced by small interfering RNA ( siRNA ) -mediated depletion of the GnRH receptor