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CREB1 — GNRH1

Text-mined interactions from Literome

Duan et al., Mol Endocrinol 1999 : In this study, we assessed the roles of estradiol and GnRH in the regulation of CREB phosphorylation in the rat pituitary ... In alphaT3 gonadotrope cells, estradiol had no direct effect on CREB phosphorylation, whereas GnRH increased CREB phosphorylation 4- to 5-fold within 5 min ... We conclude that estradiol inhibits CREB phosphorylation in the gonadotrope, probably by inhibiting GnRH production
Song et al., Mol Cell Endocrinol 2003 : CREB was shown to bind to the SgII CRE and transfection studies with a dominant negative CREB mutant provided evidence that CREB is required for GnRH responsiveness of the SgII promoter
Neithardt et al., J Cell Physiol 2006 : Dependence of GnRH induced phosphorylation of CREB and BAD on EGF receptor transactivation in GT1-7 neuronal cells ... Both GnRH and epidermal growth factor (EGF) caused rapid phosphorylation of cyclic AMP response element binding protein ( CREB ) and BAD ... These data reveal novel signaling mechanisms of GnRH induced phosphorylation of CREB and BAD in GT1-7 neurons through transactivation of the EGF-R
Shafiee-Kermani et al., Endocrinology 2007 : In addition, GnRH , forskolin, or PMA increased the expression of a CREB-responsive reporter gene, 6xCRE-37PRL-Luc
Pnueli et al., Mol Cell Biol 2011 : GnRH induces calcineurin dependent nuclear import of NFAT3, which activates the aGSU promoter, while TORC1 also mediates GnRH activation of this promoter, but not through CREB
Thompson et al., Mol Endocrinol 2013 : cAMP response element binding protein ( CREB ) has been implicated in the regulation of FSHß gene expression, but the molecular mechanisms by which pulsatile GnRH regulates CREB activation remain poorly understood ... We hypothesized that CREB is activated by a distinct signaling pathway in response to pulsatile GnRH in a frequency dependent manner to dictate the FSHß transcriptional response ... Taken together, these data indicate that a PKA mediated signaling pathway mediates GnRH activation of CREB at low-pulse frequencies, playing a significant role in the decoding of the hypothalamic GnRH signal to result in frequency dependent FSHß activation