Gene interactions and pathways from curated databases and text-mining

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GNB2L1 — IGF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hermanto et al., Mol Cell Biol 2002 : In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in response to IGF-I and phorbol 12-myristate 13-acetate stimulation ... While IGF-I induced activation of IRS-1, Shc, PI3K, and MAPK pathways was unaffected, IGF-I-inducible beta1 integrin associated kinase activity and association of Crk with p130 ( CAS ) were significantly inhibited by RACK1 overexpression
Kiely et al., Mol Cell Biol 2006 : Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration ... To address the mechanism of RACK1 function, we searched for regulatory proteins that associate with RACK1 in an IGF-I dependent manner
O'Donovan et al., Cell Signal 2007 : Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR ... Overall, the data indicate that in H9c2 cells RACK1 can influence cell size, cell survival, adhesion, migration, but its responses to IGF-I are independent of an association with the IGF-IR ... Thus, the composition of the RACK1 scaffolding complex and its effects on IGF-I signalling may be different in transformed and non transformed cells
Kurabayashi et al., PloS one 2013 : The interaction of the receptor for activated C kinase (RACK) 1, which predominantly binds to VHL, was enhanced in VHL-KO livers with IGF-IR, because VHL deletion increased free RACK1 and facilitated the IGF-IR-RACKI interaction
Eicheler et al., Acta Derm Venereol 1997 : Neither, IL-1 beta nor IGF had an effect on PKC or RACK1 expression