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GNB2L1 — IGF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1)
→
PKC mu (PRKD1)
(modification, activates)
Hermanto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1)
→
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1)
(modification, collaborate)
Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
Evidence: assay, physical interaction
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1)
→
RACK1 (GNB2L1)
(modification, collaborate)
Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
Evidence: assay, physical interaction
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1)
→
RACK1 (GNB2L1)
(modification, collaborate)
Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
Evidence: assay, physical interaction
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1)
→
PKC delta (PRKCD)
(modification, activates)
Hermanto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
Text-mined interactions from Literome
Hermanto et al., Mol Cell Biol 2002
:
In several types of mammalian cells,
RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in
response to
IGF-I and phorbol 12-myristate 13-acetate stimulation ... While IGF-I induced activation of IRS-1, Shc, PI3K, and MAPK pathways was unaffected,
IGF-I-inducible beta1 integrin associated kinase activity and association of Crk with p130 ( CAS ) were significantly
inhibited by
RACK1 overexpression
Kiely et al., Mol Cell Biol 2006
:
Insulin-like growth factor I controls a mutually exclusive association of
RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration ... To address the mechanism of RACK1 function, we searched for regulatory proteins that associate with
RACK1 in an
IGF-I dependent manner
O'Donovan et al., Cell Signal 2007
:
Effects of
RACK1 on cell migration and
IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR ... Overall, the data indicate that in H9c2 cells
RACK1 can influence cell size, cell survival, adhesion, migration, but its responses to IGF-I are
independent of an association with the
IGF-IR ... Thus, the composition of the
RACK1 scaffolding complex and its
effects on
IGF-I signalling may be different in transformed and non transformed cells
Kurabayashi et al., PloS one 2013
:
The interaction of the
receptor for activated C kinase (RACK) 1, which predominantly binds to VHL, was
enhanced in VHL-KO livers with IGF-IR, because VHL deletion increased free RACK1 and facilitated the
IGF-IR-RACKI interaction
Eicheler et al., Acta Derm Venereol 1997
:
Neither, IL-1 beta nor
IGF had an effect on PKC or
RACK1 expression